Armc10 armadillo repeat containing 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Armc10provided by MGI
Official Full Name: armadillo repeat containing 10provided by MGI
Primary source: MGI:MGI:1914461
See related: Ensembl:ENSMUSG00000038525 AllianceGenome:MGI:1914461
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Svh; 2810037C14Rik
Summary: Predicted to enable DNA binding domain binding activity and p53 binding activity. Predicted to be involved in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator and positive regulation of growth rate. Located in mitochondrion. Is expressed in several structures, including central nervous system; hindlimb bud; lung; mesenchyme derived from neural crest; and submandibular gland primordium. Orthologous to human ARMC10 (armadillo repeat containing 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 37.9), ovary adult (RPKM 34.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A3; 5 9.97 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (21851004..21867697)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (21646006..21662699)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC-derived sensory neurons.
Title: The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC-derived sensory neurons.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding domain binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth rate	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: armadillo repeat-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363422.1 → NP_001350351.1 armadillo repeat-containing protein 10 isoform 2

Status: VALIDATED

Source sequence(s)

AC161484

Related

ENSMUSP00000120269.2, ENSMUST00000148873.8

Conserved Domains (2) summary

sd00043
Location:47 → 73

ARM; armadillo repeat [structural motif]

pfam04826
Location:43 → 284

Arm_2; Armadillo-like
NM_026034.5 → NP_080310.1 armadillo repeat-containing protein 10 isoform 1

See identical proteins and their annotated locations for NP_080310.1

Status: VALIDATED

Source sequence(s)

AC161484

Consensus CDS

CCDS19104.1

UniProtKB/Swiss-Prot

Q80ZY2, Q9CUN3, Q9CZ87, Q9D0L7

Related

ENSMUSP00000072669.7, ENSMUST00000072896.13

Conserved Domains (3) summary

cd00020
Location:53 → 138

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam04826
Location:50 → 298

Arm_2; Armadillo-like

sd00043
Location:54 → 87

ARM; armadillo repeat [structural motif]