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    Nppb natriuretic peptide type B [ Mus musculus (house mouse) ]

    Gene ID: 18158, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nppbprovided by MGI
    Official Full Name
    natriuretic peptide type Bprovided by MGI
    Primary source
    MGI:MGI:97368
    See related
    Ensembl:ENSMUSG00000029019 AllianceGenome:MGI:97368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BNF; BNP; Iso-ANP
    Summary
    This gene encodes a secreted protein that belongs to the family of natriuretic peptides. Its precursor protein is processed to generate the active mature peptide. The mature peptide is a cardiac hormone that plays a role in ventricular remodeling as well as blood pressure regulation. Mice lacking this gene exhibit cardiac fibrosis. In humans this gene is associated with congestive heart failure, low bone-mineral density and postmenopausal osteoporosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
    Expression
    Restricted expression toward heart adult (RPKM 51.3) See more
    Orthologs
    NEW
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    Genomic context

    See Nppb in Genome Data Viewer
    Location:
    4 E1; 4 78.57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148070264..148071662)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (147985786..147987205)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_12062 Neighboring gene RIKEN cDNA 2510039O18 gene Neighboring gene STARR-positive B cell enhancer ABC_E2145 Neighboring gene natriuretic peptide type A Neighboring gene chloride channel, voltage-sensitive 6 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel diameter maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of cGMP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in coronary vasculature development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in homeostasis of number of cells IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cholangiocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of collecting lymphatic vessel constriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of urine volume ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor guanylyl cyclase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor guanylyl cyclase signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to oxygen levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    natriuretic peptides B
    Names
    brain natriuretic factor prohormone
    brain natriuretic peptide
    gamma-brain natriuretic peptide
    natriuretic peptide precursor type B
    preproBNP
    proBNP
    type-B natriuretic factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287348.2NP_001274277.1  natriuretic peptides B isoform 2 preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded protein (isoform 2, also known as Short isoform) is shorter than isoform 1.
      Source sequence(s)
      AL714013
      UniProtKB/TrEMBL
      O55086
      Conserved Domains (1) summary
      pfam00212
      Location:84114
      ANP; Atrial natriuretic peptide
    2. NM_008726.6NP_032752.1  natriuretic peptides B isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_032752.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as Long isoform).
      Source sequence(s)
      AL714013
      Consensus CDS
      CCDS18926.1
      UniProtKB/Swiss-Prot
      P40753
      UniProtKB/TrEMBL
      O55086, Q54AE9
      Related
      ENSMUSP00000099521.5, ENSMUST00000103231.5
      Conserved Domains (1) summary
      pfam00212
      Location:85115
      ANP; Atrial natriuretic peptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148070264..148071662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538627.5XP_006538690.1  natriuretic peptides B isoform X1

      UniProtKB/TrEMBL
      O55086
      Conserved Domains (1) summary
      pfam00212
      Location:85115
      ANP; Atrial natriuretic peptide