Slc27a5 solute carrier family 27 (fatty acid transporter), member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc27a5provided by MGI
Official Full Name: solute carrier family 27 (fatty acid transporter), member 5provided by MGI
Primary source: MGI:MGI:1347100
See related: Ensembl:ENSMUSG00000030382 AllianceGenome:MGI:1347100
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FATP5; FACVL3; VLCSH2; Vlacsr; VLCS-H2
Summary: Enables cholate-CoA ligase activity and fatty acid transmembrane transporter activity. Acts upstream of or within several processes, including ketone body biosynthetic process; long-chain fatty acid import across plasma membrane; and triglyceride mobilization. Located in basal plasma membrane. Is expressed in liver. Orthologous to human SLC27A5 (solute carrier family 27 member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward liver adult (RPKM 472.5) See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 7.71 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (12722273..12732119, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (12988346..12998192, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FATP5 Is Indispensable for the Growth of Intrahepatic Cholangiocarcinoma.
Title: FATP5 Is Indispensable for the Growth of Intrahepatic Cholangiocarcinoma.
Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis via Unconjugated Cholic Acid.
Title: Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis via Unconjugated Cholic Acid.
Fatp5 knockdown lead to a 100-fold increase in ratio of unconjugated to conjugated bile acids in ApoB defficient mice
Title: ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5).
Slc27a5, also known as fatty acid transport protein 5 (FATP5), is the hepatic BA-CoA ligase involved in reconjugating BAs during enterohepatic BA recycling
Title: Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy.
Efficient hepatocellular uptake of long-chain fatty acids, and thus liver lipid homeostasis in general, is largely protein-mediated process requiring fatty acid transport protein 5 (FATP5).
Title: Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis.
continued activity of hepatic fatty acid transport protein 5 is required to sustain caloric uptake and fatty acid flux into the liver during high fat feeding
Title: Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia.
Important role for fatty acid transport protein 5(FATP5) in bile acid conjugation in vivo and an unexpected function in body weight homeostasis.
Title: Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

AJ223959 (e-PCR)
- UniSTS:163408

NoName (e-PCR)
- UniSTS:488543

Slc27a5 (e-PCR), detects polymorphism
- UniSTS:527547

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cholate-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cholate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables fatty acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid-CoA ligase activity	TAS Traceable Author Statement more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables very long-chain fatty acid-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables very long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bile acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bile acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ketone body biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within long-chain fatty acid import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within long-chain fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within triglyceride mobilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in very long-chain fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: long-chain fatty acid transport protein 5

Names: BA-CoA ligase; BACS; BAL; FATP-5; VLACS-related; bile acid-CoA ligase; bile acyl-CoA synthetase; cholate--CoA ligase; fatty acid transport protein 5; long-chain-fatty-acid--CoA ligase; solute carrier family 27 member 5; very long-chain acyl-CoA synthetase-related protein; very long-chain acyl-Coenzyme A dehydrogenase synthase related

NP_033538.2

EC 6.2.1.3

EC 6.2.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009512.2 → NP_033538.2 long-chain fatty acid transport protein 5

See identical proteins and their annotated locations for NP_033538.2

Status: VALIDATED

Source sequence(s)

AI173562, AK144301, BC145825

Consensus CDS

CCDS20821.1

UniProtKB/Swiss-Prot

A6H6C1, O88694, Q4LDG0, Q91VD5

UniProtKB/TrEMBL

Q14C57

Related

ENSMUSP00000032539.8, ENSMUST00000032539.14

Conserved Domains (2) summary

PRK08279
Location:100 → 685

PRK08279; long-chain-acyl-CoA synthetase; Validated

cl17068
Location:139 → 679

AFD_class_I; Adenylate forming domain, Class I superfamily