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    Exosc10 exosome component 10 [ Mus musculus (house mouse) ]

    Gene ID: 50912, updated on 3-Dec-2024

    Summary

    Official Symbol
    Exosc10provided by MGI
    Official Full Name
    exosome component 10provided by MGI
    Primary source
    MGI:MGI:1355322
    See related
    Ensembl:ENSMUSG00000017264 AllianceGenome:MGI:1355322
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p2; p3; p4; RRP6; PM-Scl; Pmscl2; PM/Scl-100
    Summary
    Predicted to enable 3'-5'-RNA exonuclease activity; single-stranded RNA binding activity; and telomerase RNA binding activity. Acts upstream of or within positive regulation of mRNA cis splicing, via spliceosome. Predicted to be located in cytosol; euchromatin; and nucleoplasm. Predicted to be part of nuclear exosome (RNase complex) and small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including cerebral cortex; gonad; liver; metanephros; and muscle tissue. Orthologous to human EXOSC10 (exosome component 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 12.4), CNS E14 (RPKM 12.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Exosc10 in Genome Data Viewer
    Location:
    4 E2; 4 78.76 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148642870..148666854)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148558419..148582401)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene mechanistic target of rapamycin kinase Neighboring gene predicted gene, 24002 Neighboring gene STARR-positive B cell enhancer ABC_E1668 Neighboring gene predicted gene, 23318 Neighboring gene MBL associated serine protease 2 Neighboring gene spermidine synthase Neighboring gene TAR DNA binding protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5'-RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables telomerase RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in CUT catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in CUT catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TRAMP-dependent tRNA surveillance pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in histone mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone mRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in maturation of 5.8S rRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear mRNA surveillance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear mRNA surveillance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear polyadenylation-dependent CUT catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear polyadenylation-dependent antisense transcript catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear polyadenylation-dependent rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear polyadenylation-dependent snRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear polyadenylation-dependent snoRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in poly(A)-dependent snoRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of mRNA cis splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of telomerase RNA localization to Cajal body IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of telomerase RNA localization to Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of cytoplasmic exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in euchromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    part_of exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    part_of exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of nuclear exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of nucleolar exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    exosome complex component 10
    Names
    P100 polymyositis-scleroderma overlap syndrome associated autoantigen homolog
    autoantigen PM/Scl 2 homolog
    polymyositis/scleroderma autoantigen 2 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355489.2NP_001342418.1  exosome complex component 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606969, AL713995
      UniProtKB/TrEMBL
      Q3UNK6
      Conserved Domains (3) summary
      cd06147
      Location:202391
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:420500
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:147
      PMC2NT; PMC2NT (NUC016) domain
    2. NM_001355490.2NP_001342419.1  exosome complex component 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606969, AL713995
      Consensus CDS
      CCDS89857.1
      UniProtKB/TrEMBL
      Q3UNK6, Q8K366
      Related
      ENSMUSP00000075401.7, ENSMUST00000076022.7
      Conserved Domains (3) summary
      cd06147
      Location:285474
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:503583
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:46130
      PMC2NT; PMC2NT (NUC016) domain
    3. NM_001424999.1NP_001411928.1  exosome complex component 10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL606969, AL713995
      UniProtKB/TrEMBL
      Q3UNK6
    4. NM_001425000.1NP_001411929.1  exosome complex component 10 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL606969, AL713995
      UniProtKB/TrEMBL
      Q3UNK6
    5. NM_001425001.1NP_001411930.1  exosome complex component 10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL606969, AL713995
      UniProtKB/TrEMBL
      Q3UNK6
    6. NM_016699.4NP_057908.2  exosome complex component 10 isoform 1

      See identical proteins and their annotated locations for NP_057908.2

      Status: VALIDATED

      Source sequence(s)
      AL606969, AL713995
      Consensus CDS
      CCDS18939.1
      UniProtKB/Swiss-Prot
      B1ARY9, P56960, Q9QYS8, Q9R0B1
      UniProtKB/TrEMBL
      Q3UNK6
      Related
      ENSMUSP00000017408.8, ENSMUST00000017408.14
      Conserved Domains (3) summary
      cd06147
      Location:285474
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:503583
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:46132
      PMC2NT; PMC2NT (NUC016) domain

    RNA

    1. NR_131061.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606969, AL713995
      Related
      ENSMUST00000097781.11
    2. NR_189026.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606969, AL713995
      Related
      ENSMUST00000173154.8
    3. NR_189027.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606969, AL713995

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148642870..148666854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539023.5XP_006539086.1  exosome complex component 10 isoform X1

      UniProtKB/TrEMBL
      Q3UNK6
      Conserved Domains (3) summary
      cd06147
      Location:285474
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:503583
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:46133
      PMC2NT; PMC2NT (NUC016) domain
    2. XM_006539024.3XP_006539087.1  exosome complex component 10 isoform X2

      UniProtKB/TrEMBL
      Q3UNK6
      Conserved Domains (3) summary
      cd06147
      Location:202391
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:420500
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:150
      PMC2NT; PMC2NT (NUC016) domain
    3. XM_011250300.4XP_011248602.1  exosome complex component 10 isoform X3

      Conserved Domains (2) summary
      cd06147
      Location:59248
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:277357
      HRDC; Helicase and RNase D C-terminal

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_131062.2: Suppressed sequence

      Description
      NR_131062.2: This RefSeq was removed because currently there is insufficient support for the transcript.