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    Poc1b POC1 centriolar protein B [ Mus musculus (house mouse) ]

    Gene ID: 382406, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Poc1bprovided by MGI
    Official Full Name
    POC1 centriolar protein Bprovided by MGI
    Primary source
    MGI:MGI:1918511
    See related
    Ensembl:ENSMUSG00000019952 AllianceGenome:MGI:1918511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr51b; 4933430F16Rik
    Summary
    Acts upstream of or within several processes, including homeostasis of number of cells; single fertilization; and spermatid development. Predicted to be located in centrosome and spindle pole. Predicted to be active in centriole and ciliary basal body. Is expressed in ductus deferens; epididymis; ileum; metanephros; and testis. Used to study oligoasthenoteratozoospermia. Human ortholog(s) of this gene implicated in cone-rod dystrophy 20. Orthologous to human POC1B (POC1 centriolar protein B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 19.9), CNS E11.5 (RPKM 7.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Poc1b in Genome Data Viewer
    Location:
    10 C3- D1; 10 51.06 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (98942918..99033936)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (99107082..99198074)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr10:98376846-98377147 Neighboring gene predicted gene, 53607 Neighboring gene ATPase, Ca++ transporting, plasma membrane 1 Neighboring gene STARR-positive B cell enhancer ABC_E3912 Neighboring gene STARR-seq mESC enhancer starr_27702 Neighboring gene STARR-seq mESC enhancer starr_27703 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98589429-98589538 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98590442-98590625 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98594927-98595144 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 4 Neighboring gene STARR-seq mESC enhancer starr_27706 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98634758-98634867 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98644928-98645081 Neighboring gene STARR-positive B cell enhancer ABC_E6916 Neighboring gene predicted gene 16239 Neighboring gene STARR-positive B cell enhancer mm9_chr10:98667182-98667482 Neighboring gene STARR-seq mESC enhancer starr_27708 Neighboring gene predicted gene, 34574 Neighboring gene predicted gene, 34777

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice. Hua J, et al. Hum Mol Genet, 2023 Jul 4. PMID 37070736
    2. Biallelic mutations in PMFBP1 cause acephalic spermatozoa. Sha YW, et al. Clin Genet, 2019 Feb. PMID 30298696
    3. Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation. Hughes DS, et al. BMC Dev Biol, 2009 May 22. PMID 19463158, Free PMC Article
    4. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice.
      Title: Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cellular component organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retina homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retina homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within sperm flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    POC1 centriolar protein homolog B
    Names
    WD repeat domain 51B
    WD repeat-containing protein 51B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027740.7 → NP_082016.1  POC1 centriolar protein homolog B

      See identical proteins and their annotated locations for NP_082016.1

      Status: VALIDATED

      Source sequence(s)
      AK050233, BC050888, BC144819, CO041491
      Consensus CDS
      CCDS36045.1
      UniProtKB/Swiss-Prot
      Q8BHD1
      UniProtKB/TrEMBL
      A6H699
      Related
      ENSMUSP00000020113.9, ENSMUST00000020113.15
      Conserved Domains (3) summary
      COG2319
      Location:14 → 300
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:10 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:63 → 100
      7WD40; WD40 repeat [structural motif]

    RNA

    1. NR_153333.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC050888, BC144819, CO041491

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      98942918..99033936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155881.1 → XP_036011774.1  POC1 centriolar protein homolog B isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:15 → 51
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:4 → 84
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHD1.1 GenPept UniProtKB/Swiss-Prot:Q8BHD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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