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    Draxin dorsal inhibitory axon guidance protein [ Mus musculus (house mouse) ]

    Gene ID: 70433, updated on 9-Dec-2024

    Summary

    Official Symbol
    Draxinprovided by MGI
    Official Full Name
    dorsal inhibitory axon guidance proteinprovided by MGI
    Primary source
    MGI:MGI:1917683
    See related
    Ensembl:ENSMUSG00000029005 AllianceGenome:MGI:1917683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    neucrin; 2610109H07Rik
    Summary
    Predicted to enable molecular adaptor activity. Involved in negative regulation of canonical Wnt signaling pathway; negative regulation of neuron projection development; and nervous system development. Acts upstream of or within negative regulation of axon extension and negative regulation of hippocampal neuron apoptotic process. Located in extracellular region. Is expressed in several structures, including central nervous system; dorsal root ganglion; future brain; neural retina; and vibrissa. Orthologous to human DRAXIN (dorsal inhibitory axon guidance protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 14.9), CNS E14 (RPKM 13.3) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Draxin in Genome Data Viewer
    Location:
    4 E1- E2; 4 78.67 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148182894..148215582, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148098437..148131139, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13201 Neighboring gene STARR-positive B cell enhancer ABC_E6283 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4727 Neighboring gene STARR-seq mESC enhancer starr_12067 Neighboring gene angiotensin II, type I receptor-associated protein Neighboring gene STARR-seq mESC enhancer starr_12068 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:147472153-147472360 Neighboring gene MAD2 mitotic arrest deficient-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E2146 Neighboring gene STARR-positive B cell enhancer ABC_E4728 Neighboring gene microRNA 7022 Neighboring gene F-box protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E3553 Neighboring gene F-box protein 44 Neighboring gene F-box protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterior commissure morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in commissural neuron differentiation in spinal cord IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in commissural neuron differentiation in spinal cord IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dorsal spinal cord development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dorsal spinal cord development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in forebrain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of hippocampal neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of axon extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of hippocampal neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    draxin
    Names
    dorsal repulsive axon guidance protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027426.3NP_081702.2  draxin precursor

      See identical proteins and their annotated locations for NP_081702.2

      Status: VALIDATED

      Source sequence(s)
      BC058734, BC060239, BY728334
      Consensus CDS
      CCDS18931.1
      UniProtKB/Swiss-Prot
      A2A7G4, B2KFL9, Q6PAL1, Q8C3D8
      Related
      ENSMUSP00000030862.5, ENSMUST00000030862.5
      Conserved Domains (1) summary
      pfam15550
      Location:38343
      Draxin; Draxin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148182894..148215582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539170.5XP_006539233.1  draxin isoform X1

      Conserved Domains (1) summary
      pfam15550
      Location:60365
      Draxin