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    Macroh2a3 macroH2A.3 histone [ Mus musculus (house mouse) ]

    Gene ID: 67552, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Macroh2a3provided by MGI
    Official Full Name
    macroH2A.3 histoneprovided by MGI
    Primary source
    MGI:MGI:1914802
    See related
    AllianceGenome:MGI:1914802
    Gene type
    pseudo
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H2afy3; 4933432H23Rik
    Summary
    Is expressed in early tubule; female associated reproductive structure; and male associated reproductive structure. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Macroh2a3 in Genome Data Viewer
    Location:
    15 D1; 15 26.42 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (62089390..62091300, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (62217541..62219451, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38818 Neighboring gene STARR-seq mESC enhancer starr_38819 Neighboring gene STARR-seq mESC enhancer starr_38820 Neighboring gene myelocytomatosis oncogene Neighboring gene STARR-seq mESC enhancer starr_38824 Neighboring gene Pvt1 oncogene Neighboring gene predicted gene, 53890 Neighboring gene STARR-positive B cell enhancer ABC_E5482 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:62001280-62001493 Neighboring gene STARR-positive B cell enhancer ABC_E7373 Neighboring gene STARR-positive B cell enhancer mm9_chr15:62013150-62013450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:62044000-62044201 Neighboring gene STARR-seq mESC enhancer starr_38830 Neighboring gene STARR-positive B cell enhancer mm9_chr15:62189952-62190252 Neighboring gene STARR-seq mESC enhancer starr_38831 Neighboring gene STARR-seq mESC enhancer starr_38832 Neighboring gene STARR-seq mESC enhancer starr_38833 Neighboring gene STARR-seq mESC enhancer starr_38834 Neighboring gene predicted gene, 41333 Neighboring gene STARR-seq mESC enhancer starr_38835 Neighboring gene predicted gene, 22521

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping. Filipescu D, et al. Nat Cell Biol, 2023 Sep. PMID 37605008, Free PMC Article
    2. Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. Chadwick BP, et al. Hum Mol Genet, 2001 May 1. PMID 11331621
    3. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping.
      Title: MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • H2A histone family, member Y3
    • macroH2A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003523.1 RNA Sequence

      Status: PROVISIONAL

      Source sequence(s)
      AC133090

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      62089390..62091300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026230.2: Suppressed sequence

      Description
      NM_026230.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein Strain
    Heading Accession and Version

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