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    Agtrap angiotensin II, type I receptor-associated protein [ Mus musculus (house mouse) ]

    Gene ID: 11610, updated on 9-Dec-2024

    Summary

    Official Symbol
    Agtrapprovided by MGI
    Official Full Name
    angiotensin II, type I receptor-associated proteinprovided by MGI
    Primary source
    MGI:MGI:1339977
    See related
    Ensembl:ENSMUSG00000029007 AllianceGenome:MGI:1339977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AT1R; Atrap; D4Wsu124e; 3300002E14Rik
    Summary
    Enables angiotensin type II receptor activity. Acts upstream of or within regulation of blood pressure. Located in cell cortex and plasma membrane. Is expressed in several structures, including genitourinary system; ileum; liver; lung; and spleen. Used to study acquired metabolic disease. Orthologous to human AGTRAP (angiotensin II receptor associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 26.3), kidney adult (RPKM 17.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Agtrap in Genome Data Viewer
    Location:
    4 E1; 4 78.67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148161518..148172521, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148077061..148088064, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Mthfr promoter region Neighboring gene methylenetetrahydrofolate reductase Neighboring gene predicted gene 13201 Neighboring gene STARR-positive B cell enhancer ABC_E6283 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4727 Neighboring gene STARR-seq mESC enhancer starr_12067 Neighboring gene STARR-seq mESC enhancer starr_12068 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:147472153-147472360 Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene MAD2 mitotic arrest deficient-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E2146 Neighboring gene microRNA 7022 Neighboring gene F-box protein 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables angiotensin type II receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiotensin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    type-1 angiotensin II receptor-associated protein
    Names
    AT1 receptor-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301281.1NP_001288210.1  type-1 angiotensin II receptor-associated protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR that causes translation initiation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL606929
      Conserved Domains (1) summary
      cl05741
      Location:1106
      AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)
    2. NM_009642.5NP_033772.2  type-1 angiotensin II receptor-associated protein isoform 1

      See identical proteins and their annotated locations for NP_033772.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK152467, AL606929, CO040736
      Consensus CDS
      CCDS18930.1
      UniProtKB/Swiss-Prot
      B2KFL8, Q3U7X6, Q9D8Z8, Q9D940, Q9WVK0
      Related
      ENSMUSP00000030865.9, ENSMUST00000030865.9
      Conserved Domains (1) summary
      smart00805
      Location:1161
      AGTRAP; Angiotensin II, type I receptor-associated protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148161518..148172521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)