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    Angel1 angel homolog 1 [ Mus musculus (house mouse) ]

    Gene ID: 68737, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Angel1provided by MGI
    Official Full Name
    angel homolog 1provided by MGI
    Primary source
    MGI:MGI:1915987
    See related
    Ensembl:ENSMUSG00000021257 AllianceGenome:MGI:1915987
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0759; 1110030H02Rik
    Summary
    Predicted to enable eukaryotic initiation factor 4E binding activity; mRNA 3'-UTR binding activity; and protein domain specific binding activity. Predicted to be located in several cellular components, including cis-Golgi network; endoplasmic reticulum; and perinuclear region of cytoplasm. Is expressed in cerebral cortex marginal layer; dorsal root ganglion; orbito-sphenoid; and trigeminal ganglion. Orthologous to human ANGEL1 (angel homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 73.7) and cerebellum adult (RPKM 4.0) See more
    Orthologs
    human all
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    Genomic context

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    See Angel1 in Genome Data Viewer
    Location:
    12 D2; 12 40.86 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (86740185..86781075, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (86699719..86734303, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:88000594-88000875 Neighboring gene poly(rC) binding protein 2 pseudogene Neighboring gene predicted gene, 22004 Neighboring gene STARR-seq mESC enhancer starr_32830 Neighboring gene vasohibin 1 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5342 Neighboring gene predicted gene, 32755 Neighboring gene leucine rich repeat containing 74A Neighboring gene STARR-positive B cell enhancer ABC_E5343 Neighboring gene STARR-positive B cell enhancer ABC_E1448 Neighboring gene STARR-seq mESC enhancer starr_32839 Neighboring gene predicted gene, 53733

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0759

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic initiation factor 4E binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables eukaryotic initiation factor 4E binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein angel homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144524.2 → NP_653107.2  protein angel homolog 1

      See identical proteins and their annotated locations for NP_653107.2

      Status: VALIDATED

      Source sequence(s)
      AK143549, BQ175854, BY194341, CF173918
      Consensus CDS
      CCDS26067.1
      UniProtKB/Swiss-Prot
      Q5DU16, Q8VCU0
      Related
      ENSMUSP00000021682.9, ENSMUST00000021682.9
      Conserved Domains (1) summary
      cl00490
      Location:245 → 660
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      86740185..86781075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516199.5 → XP_006516262.1  protein angel homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_006516262.1

      UniProtKB/TrEMBL
      A0AAQ4VMR1
      Conserved Domains (1) summary
      cl00490
      Location:258 → 673
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. XM_030246896.2 → XP_030102756.1  protein angel homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0AAQ4VMR1
      Related
      ENSMUSP00000159965.1, ENSMUST00000249870.1
      Conserved Domains (1) summary
      cl00490
      Location:258 → 673
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    3. XM_011244169.3 → XP_011242471.1  protein angel homolog 1 isoform X1

      Conserved Domains (1) summary
      cl00490
      Location:268 → 683
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    4. XM_006516200.5 → XP_006516263.1  protein angel homolog 1 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:199 → 614
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCU0.2 GenPept UniProtKB/Swiss-Prot:Q8VCU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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