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    THR1 homoserine kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    THR1
    Official Full Name
    homoserine kinase
    Primary source
    SGD:S000001067
    Locus tag
    YHR025W
    See related
    AllianceGenome:SGD:S000001067; FungiDB:YHR025W; VEuPathDB:YHR025W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables homoserine kinase activity. Involved in homoserine metabolic process and threonine biosynthetic process. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See THR1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (159438..160511)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene myosin 1 Neighboring gene mitochondrial-processing protease subunit alpha Neighboring gene H(+)-transporting V0 sector ATPase subunit c'' Neighboring gene proteasome regulatory particle base subunit RPN1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of yeast cloned genes by genetic analysis. Martín-Rendón E, et al. Microbiologia, 1992 Nov. PMID 1337256
    2. Yeast homoserine kinase. Characteristics of the corresponding gene, THR1, and the purified enzyme, and evolutionary relationships with other enzymes of threonine metabolism. Mannhaupt G, et al. Eur J Biochem, 1990 Jul 20. PMID 2165904
    3. Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases. Schultes NP, et al. Gene, 1990 Dec 15. PMID 2176637
    4. Inhibition by different amino acids of the aspartate kinase and the homoserine kinase of the yeast Saccharomyces cerevisiae. Ramos C, et al. FEBS Lett, 1991 Jan 14. PMID 1847111
    5. Substrate specificity and identification of functional groups of homoserine kinase from Escherichia coli. Huo X, et al. Biochemistry, 1996 Dec 17. PMID 8973190

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables homoserine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables homoserine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in homoserine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in threonine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in threonine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    homoserine kinase
    NP_011890.1
    • Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      159438..160511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179155.1 → NP_011890.1  TPA: homoserine kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011890.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKX2, P17423
      UniProtKB/TrEMBL
      A6ZST1, B3LSE6, B5VJV5, C7GTV5, C8ZA93, G2WF96, N1P9L5
      Conserved Domains (1) summary
      TIGR00191
      Location:5 → 355
      thrB; homoserine kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17423.4

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