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    PRP11 Prp11p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851518, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PRP11
    Official Full Name
    Prp11p
    Primary source
    SGD:S000002201
    Locus tag
    YDL043C
    See related
    AllianceGenome:SGD:S000002201; FungiDB:YDL043C; VEuPathDB:YDL043C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RNA11
    Summary
    Enables RNA binding activity. Involved in spliceosomal complex assembly. Part of U2-type prespliceosome. Orthologous to human SF3A2 (splicing factor 3a subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PRP11 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (375680..376480, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene FMN adenylyltransferase Neighboring gene Mtf2p Neighboring gene NAD-dependent histone deacetylase SIR2 Neighboring gene peptide alpha-N-acetyltransferase complex A subunit NAT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutants of yeast with depressed DNA synthesis. Johnston LH, et al. Mol Gen Genet, 1978 May 3. PMID 353510
    2. RNA11 protein is associated with the yeast spliceosome and is localized in the periphery of the cell nucleus. Chang TH, et al. Mol Cell Biol, 1988 Jun. PMID 3043176, Free PMC Article
    3. The yeast MUD2 protein: an interaction with PRP11 defines a bridge between commitment complexes and U2 snRNP addition. Abovich N, et al. Genes Dev, 1994 Apr 1. PMID 7926772
    4. Interactions between highly conserved U2 small nuclear RNA structures and Prp5p, Prp9p, Prp11p, and Prp21p proteins are required to ensure integrity of the U2 small nuclear ribonucleoprotein in Saccharomyces cerevisiae. Wells SE, et al. Mol Cell Biol, 1994 Sep. PMID 8065365, Free PMC Article
    5. Interaction between PRP11 and SPP91 yeast splicing factors and characterization of a PRP9-PRP11-SPP91 complex. Legrain P, et al. Science, 1993 Oct 1. PMID 8211114

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Prp11p
    NP_010241.1
    • Subunit of the SF3a splicing factor complex; required for spliceosome assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      375680..376480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180102.1 → NP_010241.1  TPA: Prp11p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010241.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRV3, Q05434, Q07350
      UniProtKB/TrEMBL
      B3LGU1, B5VFM4, C7GPW2, C8Z4M7, G2WCB8, N1P7T3
      Conserved Domains (1) summary
      COG5246
      Location:1 → 262
      PRP11; Splicing factor 3a, subunit 2 [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07350.1

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