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    FRD1 fumarate reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856664, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FRD1
    Official Full Name
    fumarate reductase
    Primary source
    SGD:S000000773
    Locus tag
    YEL047C
    See related
    AllianceGenome:SGD:S000000773; FungiDB:YEL047C; VEuPathDB:YEL047C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables fumarate reductase (NADH) activity. Involved in cellular response to anoxia. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FRD1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (65385..66797, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene seripauperin PAU2 Neighboring gene Tca17p Neighboring gene threonine aldolase GLY1 Neighboring gene Ies6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequencing of the gene encoding the soluble fumarate reductase from Saccharomyces cerevisiae. Enomoto K, et al. DNA Res, 1996 Aug 31. PMID 8946166
    2. Role in anaerobiosis of the isoenzymes for Saccharomyces cerevisiae fumarate reductase encoded by OSM1 and FRDS1. Camarasa C, et al. Yeast, 2007 May. PMID 17345583
    3. Effect of gene disruptions of the TCA cycle on production of succinic acid in Saccharomyces cerevisiae. Arikawa Y, et al. J Biosci Bioeng, 1999. PMID 16232421
    4. Role of the AFRD1-encoded fumarate reductase in hypoxia and osmotolerance in Arxula adeninivorans. Sędzielewska KA, et al. FEMS Yeast Res, 2012 Dec. PMID 22900669
    5. GiFRD encodes a protein involved in anaerobic growth in the arbuscular mycorrhizal fungus Glomus intraradices. Sędzielewska KA, et al. Fungal Genet Biol, 2012 Apr. PMID 22343635

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fumarate reductase (NADH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fumarate reductase (NADH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fumarate reductase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to anoxia IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    fumarate reductase
    NP_010867.3
    • Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      65385..66797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178862.3 → NP_010867.3  TPA: fumarate reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010867.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLK3, P32614
      UniProtKB/TrEMBL
      A6ZQQ4, B3LRX0, B5VH88, C7GKE9, C8Z6U7, G2WCI7, N1PA70
      Conserved Domains (1) summary
      TIGR01813
      Location:5 → 463
      flavo_cyto_c; flavocytochrome c
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32614.1

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