TRM12 tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TRM12
Official Full Name: tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase
Primary source: SGD:S000004464
Locus tag: YML005W
See related: AllianceGenome:SGD:S000004464; FungiDB:YML005W; VEuPathDB:YML005W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TYW2
Summary: Enables S-adenosylmethionine-dependent methyltransferase activity and transferase activity, transferring alkyl or aryl (other than methyl) groups. Involved in tRNA methylation and wybutosine biosynthetic process. Located in cytoplasm. Orthologous to human TRMT12 (tRNA methyltransferase 12 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TRM12 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (260221..261609)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables S-adenosylmethionine-dependent methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring alkyl or aryl (other than methyl) groups	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA modification	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in wybutosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in wybutosine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in wybutosine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase

NP_013709.1

EC 2.5.1.114

S-adenosylmethionine-dependent methyltransferase; required for wybutosine formation in phenylalanine-accepting tRNA; member of the seven beta-strand family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

260221..261609

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182360.1 → NP_013709.1 TPA: tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013709.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZH0, Q04235

UniProtKB/TrEMBL

A6ZM58, N1NY53

Conserved Domains (1) summary

COG2520
Location:6 → 460

Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]