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    CIA2 iron-sulfur cluster assembly protein CIA2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856522, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CIA2
    Official Full Name
    iron-sulfur cluster assembly protein CIA2
    Primary source
    SGD:S000001164
    Locus tag
    YHR122W
    See related
    AllianceGenome:SGD:S000001164; FungiDB:YHR122W; VEuPathDB:YHR122W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in iron-sulfur cluster assembly. Located in cytoplasm and nucleus. Part of cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human CIAO2B (cytosolic iron-sulfur assembly component 2B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CIA2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (353625..354320)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene mismatch repair ATPase MSH1 Neighboring gene Lsm12p Neighboring gene bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Neighboring gene transcription factor NDT80

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CIA2 deficiency results in impaired oxidative stress response and enhanced intracellular basal UPR activity in Saccharomyces cerevisiae. Zhao W, et al. FEMS Microbiol Lett, 2015 Mar. PMID 25667230
    2. Structural and biochemical investigations of a HEAT-repeat protein involved in the cytosolic iron-sulfur cluster assembly pathway. Vasquez S, et al. Commun Biol, 2023 Dec 18. PMID 38110506, Free PMC Article
    3. Defining the domains of Cia2 required for its essential function in vivo and in vitro. Vo AT, et al. Metallomics, 2017 Nov 15. PMID 29057997
    4. Reverse PCA, a systematic approach for identifying genes important for the physical interaction between protein pairs. Lev I, et al. PLoS Genet, 2013. PMID 24130505, Free PMC Article
    5. Identifying the Protein Interactions of the Cytosolic Iron-Sulfur Cluster Targeting Complex Essential for Its Assembly and Recognition of Apo-Targets. Vo A, et al. Biochemistry, 2018 Apr 24. PMID 28539047

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E208A-iron-sulfur cluster assembly protein CIA2 (Cia2) results in a diminished activity of the cytosolic iron sulfur cluster protein.
      Title: Defining the domains of Cia2 required for its essential function in vivo and in vitro.
    2. results suggest the involvement of Cia2p in oxidative and endoplasmic reticulum stress responses in yeast
      Title: CIA2 deficiency results in impaired oxidative stress response and enhanced intracellular basal UPR activity in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation by [4Fe-4S] cluster transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    part_of cytosolic [4Fe-4S] assembly targeting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    iron-sulfur cluster assembly protein CIA2
    NP_011990.1
    • Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation and maturation of a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      353625..354320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179252.1 → NP_011990.1  TPA: iron-sulfur cluster assembly protein CIA2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011990.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL72, P38829
      UniProtKB/TrEMBL
      A6ZT30, B3LSN7, B5VK57, C7GR68, C8Z9R5, N1P156
      Conserved Domains (1) summary
      COG5133
      Location:1 → 231
      COG5133; Uncharacterized conserved protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38829.1

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