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    STB3 Stb3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851747, updated on 27-Dec-2024

    Summary

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    Official Symbol
    STB3
    Official Full Name
    Stb3p
    Primary source
    SGD:S000002576
    Locus tag
    YDR169C
    See related
    AllianceGenome:SGD:S000002576; FungiDB:YDR169C; VEuPathDB:YDR169C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in cellular response to glucose stimulus and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See STB3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (792348..793889, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Taf10p Neighboring gene Cdc37p Neighboring gene uncharacterized protein Neighboring gene Arf family guanine nucleotide exchange factor SEC7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stb3 binds to ribosomal RNA processing element motifs that control transcriptional responses to growth in Saccharomyces cerevisiae. Liko D, et al. J Biol Chem, 2007 Sep 7. PMID 17616518
    2. Global Promoter Targeting of a Conserved Lysine Deacetylase for Transcriptional Shutoff during Quiescence Entry. McKnight JN, et al. Mol Cell, 2015 Sep 3. PMID 26300265, Free PMC Article
    3. Overexpression of the YAP1, PDE2, and STB3 genes enhances the tolerance of yeast to oxidative stress induced by 7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine. Drobna E, et al. FEMS Yeast Res, 2012 Dec. PMID 22909133
    4. Multiplex navigation of global regulatory networks (MINR) in yeast for improved ethanol tolerance and production. Liu R, et al. Metab Eng, 2019 Jan. PMID 30030154
    5. Stb3 plays a role in the glucose-induced transition from quiescence to growth in Saccharomyces cerevisiae. Liko D, et al. Genetics, 2010 Jul. PMID 20385783, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The overexpressed genes, YAP1, PDE2, and STB3, can enhance the tolerance of yeast cells to 7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine.
      Title: Overexpression of the YAP1, PDE2, and STB3 genes enhances the tolerance of yeast to oxidative stress induced by 7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine.
    2. Stb3 plays an important but not exclusive role in the transcriptional response to growth conditions.
      Title: Stb3 binds to ribosomal RNA processing element motifs that control transcriptional responses to growth in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sequence-specific DNA binding HDA PubMed 
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription from RNA polymerase II promoter by glucose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Stb3p
    NP_010453.1
    • Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      792348..793889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180476.1 → NP_010453.1  TPA: Stb3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSE9, Q12427
      UniProtKB/TrEMBL
      B3LGB5, B5VG64, C7GQF0
      Conserved Domains (1) summary
      pfam10330
      Location:43 → 119
      Stb3; Putative Sin3 binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12427.1

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