BET4 Rab geranylgeranyltransferase BET4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BET4
Official Full Name: Rab geranylgeranyltransferase BET4
Primary source: SGD:S000003568
Locus tag: YJL031C
See related: AllianceGenome:SGD:S000003568; FungiDB:YJL031C; VEuPathDB:YJL031C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables Rab geranylgeranyltransferase activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein geranylgeranylation; and protein targeting to membrane. Located in peroxisome. Part of Rab-protein geranylgeranyltransferase complex. Orthologous to human RABGGTA (Rab geranylgeranyltransferase subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See BET4 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 2

Sequence:: Chromosome: X; NC_001142.9 (386368..387438, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables Rab geranylgeranyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables Rab geranylgeranyltransferase activity	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein geranylgeranyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein prenyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein geranylgeranylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein geranylgeranylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Rab-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rab-protein geranylgeranyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Rab-protein geranylgeranyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Rab geranylgeranyltransferase BET4

NP_012503.2

EC 2.5.1.60

Alpha subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

386368..387438 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181465.1 → NP_012503.2 TPA: Rab geranylgeranyltransferase BET4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012503.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWF1, Q00618

UniProtKB/TrEMBL

A6ZPU4, C8ZBC8, G2WGY6

Conserved Domains (1) summary

COG5536
Location:1 → 327

BET4; Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]