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    CNM67 Cnm67p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855496, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CNM67
    Official Full Name
    Cnm67p
    Primary source
    SGD:S000005169
    Locus tag
    YNL225C
    See related
    AllianceGenome:SGD:S000005169; FungiDB:YNL225C; VEuPathDB:YNL225C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of cytoskeleton. Involved in mitotic spindle organization and spindle pole body organization. Located in outer plaque of mitotic spindle pole body. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CNM67 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (222724..224469, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase Neighboring gene Jjj1p Neighboring gene Sqs1p Neighboring gene cysteine protease ATG4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure-function analysis of the C-terminal domain of CNM67, a core component of the Saccharomyces cerevisiae spindle pole body. Klenchin VA, et al. J Biol Chem, 2011 May 20. PMID 21454609, Free PMC Article
    2. Saccharomyces cerevisiae cells with defective spindle pole body outer plaques accomplish nuclear migration via half-bridge-organized microtubules. Brachat A, et al. Mol Biol Cell, 1998 May. PMID 9571234, Free PMC Article
    3. Cnm67p is a spacer protein of the Saccharomyces cerevisiae spindle pole body outer plaque. Schaerer F, et al. Mol Biol Cell, 2001 Aug. PMID 11514632, Free PMC Article
    4. Time-lapse video microscopy analysis reveals astral microtubule detachment in the yeast spindle pole mutant cnm67. Hoepfner D, et al. Mol Biol Cell, 2000 Apr. PMID 10749924, Free PMC Article
    5. YOR129c, a new element interacting with Cnm67p, a component of the spindle pole body of Saccharomyces cerevisiae. Wysocka M, et al. Acta Biochim Pol, 2003. PMID 14515169

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure-function analysis of the C-terminal domain of CNM67, a core component of the Saccharomyces cerevisiae spindle pole body.
      Title: Structure-function analysis of the C-terminal domain of CNM67, a core component of the Saccharomyces cerevisiae spindle pole body.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle pole body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer plaque of mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer plaque of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole body HDA PubMed 
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cnm67p
    NP_014174.1
    • Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      222724..224469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183063.1 → NP_014174.1  TPA: Cnm67p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014174.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0W5, P53865
      UniProtKB/TrEMBL
      A6ZRL5, C7GPD2
      Conserved Domains (2) summary
      COG1196
      Location:168 → 440
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11778
      Location:444 → 575
      SID; Septation initiation
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53865.1

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