U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ILV3 dihydroxy-acid dehydratase ILV3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853473, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ILV3
    Official Full Name
    dihydroxy-acid dehydratase ILV3
    Primary source
    SGD:S000003777
    Locus tag
    YJR016C
    See related
    AllianceGenome:SGD:S000003777; FungiDB:YJR016C; VEuPathDB:YJR016C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables dihydroxy-acid dehydratase activity. Involved in branched-chain amino acid biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ILV3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (464451..466208, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Tma22p Neighboring gene uncharacterized protein Neighboring gene peptidylprolyl isomerase ESS1 Neighboring gene palmitoyl-CoA hydrolase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cloning of the dihydroxyacid dehydratase-encoding gene (ILV3) from Saccharomyces cerevisiae. Velasco JA, et al. Gene, 1993 Dec 31. PMID 8299945
    2. Studies on a dehydrase in valine biosynthesis in yeast. WIXOM RL, et al. J Biol Chem, 1960 Jan. PMID 13845531
    3. The Aspergillus fumigatus dihydroxyacid dehydratase Ilv3A/IlvC is required for full virulence. Oliver JD, et al. PLoS One, 2012. PMID 23028460, Free PMC Article
    4. Cytosolic re-localization and optimization of valine synthesis and catabolism enables inseased isobutanol production with the yeast Saccharomyces cerevisiae. Brat D, et al. Biotechnol Biofuels, 2012 Sep 6. PMID 22954227, Free PMC Article
    5. Specialized function of yeast Isa1 and Isa2 proteins in the maturation of mitochondrial [4Fe-4S] proteins. Mühlenhoff U, et al. J Biol Chem, 2011 Dec 2. PMID 21987576, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydroxy-acid dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydroxy-acid dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydroxy-acid dehydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-valine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branched-chain amino acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in branched-chain amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branched-chain amino acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    dihydroxy-acid dehydratase ILV3
    NP_012550.1
    • Dihydroxyacid dehydratase; putative 2Fe-2S protein; catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      464451..466208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181674.1 → NP_012550.1  TPA: dihydroxy-acid dehydratase ILV3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012550.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWJ2, P39522
      UniProtKB/TrEMBL
      A6ZPY4, B3LQB4, D3UF79, G2WH29, N1P011
      Conserved Domains (1) summary
      TIGR00110
      Location:45 → 584
      ilvD; dihydroxy-acid dehydratase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39522.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools