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    NMD3 ribosome-binding protein NMD3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856575, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NMD3
    Official Full Name
    ribosome-binding protein NMD3
    Primary source
    SGD:S000001213
    Locus tag
    YHR170W
    See related
    AllianceGenome:SGD:S000001213; FungiDB:YHR170W; VEuPathDB:YHR170W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SRC5
    Summary
    Enables large ribosomal subunit rRNA binding activity; protein-macromolecule adaptor activity; and ribosomal large subunit binding activity. Involved in ribosomal large subunit export from nucleus. Located in cytosol. Orthologous to human NMD3 (NMD3 ribosome export adaptor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NMD3 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (443828..445384)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene putative GTPase MTG2 Neighboring gene ATP-dependent RNA helicase DBP8 Neighboring gene Atg7p Neighboring gene Spc97p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit. Ho JH, et al. J Cell Biol, 2000 Nov 27. PMID 11086007, Free PMC Article
    2. Characterisation of the interaction of guanine nucleotides with ribosomal GTPase Lsg1. Jaramillo-Ramírez J, et al. Biochim Biophys Acta Proteins Proteom, 2021 Jan. PMID 32916301
    3. Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesis. Sulima SO, et al. Proc Natl Acad Sci U S A, 2014 Apr 15. PMID 24706786, Free PMC Article
    4. An improved, bias-reduced probabilistic functional gene network of baker's yeast, Saccharomyces cerevisiae. Lee I, et al. PLoS One, 2007 Oct 3. PMID 17912365, Free PMC Article
    5. Overexpression of truncated Nmd3p inhibits protein synthesis in yeast. Belk JP, et al. RNA, 1999 Aug. PMID 10445880, Free PMC Article

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterisation of the interaction of guanine nucleotides with ribosomal GTPase Lsg1.
      Title: Characterisation of the interaction of guanine nucleotides with ribosomal GTPase Lsg1.
    2. Nmd3 and Lsg1 together embrace helix 69 of the B2a intersubunit bridge, inducing base flipping that we suggest may activate the GTPase activity of Lsg1.
      Title: Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis.
    3. cryo-EM reconstruction of the 60S subunit in complex with Nmd3; is attached to the regions around helices 38, 69, and 95 of the 25S rRNA
      Title: Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit.
    4. analysis of the functional domains of yeast NMD3, the nuclear export adapter for the 60 S ribosomal subunit
      Title: Mapping the functional domains of yeast NMD3, the nuclear export adapter for the 60 S ribosomal subunit.
    5. correct loading of Rpl10p into 60S subunits is required for the release of Nmd3p from subunits by Lsg1p
      Title: Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables large ribosomal subunit rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal large subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal large subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosome-binding protein NMD3
    NP_012040.1
    • Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      443828..445384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179301.1 → NP_012040.1  TPA: ribosome-binding protein NMD3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012040.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLB9, P38861
      UniProtKB/TrEMBL
      A6ZT78, B3LST3, B5VK98, C7GJX0, C8Z9W8, G2WFP4, N1P4U9
      Conserved Domains (1) summary
      COG1499
      Location:11 → 385
      NMD3; NMD protein affecting ribosome stability and mRNA decay [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38861.3

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