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    CCE1 cruciform cutting endonuclease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853858, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CCE1
    Official Full Name
    cruciform cutting endonuclease
    Primary source
    SGD:S000001494
    Locus tag
    YKL011C
    See related
    AllianceGenome:SGD:S000001494; FungiDB:YKL011C; VEuPathDB:YKL011C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MGT1
    Summary
    Enables DNA endonuclease activity. Involved in mitochondrial genome maintenance. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CCE1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (420155..421216, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Arc19p Neighboring gene Prp40p Neighboring gene putative ubiquitin-protein ligase UFD4 Neighboring gene Mrt4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The transmission disadvantage of yeast mitochondrial intergenic mutants is eliminated in the mgt1 (cce1) background. Piskur J. J Bacteriol, 1997 Sep. PMID 9287024, Free PMC Article
    2. Yeast resolving enzyme CCE1 makes sequential cleavages in DNA junctions within the lifetime of the complex. Fogg JM, et al. Biochemistry, 2000 Apr 11. PMID 10747798
    3. Extensive central disruption of a four-way junction on binding CCE1 resolving enzyme. Déclais AC, et al. J Mol Biol, 2000 Feb 18. PMID 10669598
    4. The role of the SAP motif in promoting Holliday junction binding and resolution by SpCCE1. Ahn JS, et al. J Biol Chem, 2003 Aug 1. PMID 12748193
    5. Quantitation of metal ion and DNA junction binding to the Holliday junction endonuclease Cce1. Kvaratskhelia M, et al. Biochemistry, 1999 Dec 14. PMID 10600123

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Abf2p does not significantly affect either binding of Cce1p to branched DNA or rate and specificity of Holliday junction resolution. These data suggest the existence of an alternative homologous recombination pathway in yeast mitochondria.
      Title: Interaction between Saccharomyces cerevisiae Mitochondrial DNA-Binding Protein Abf2p and Cce1p Resolvase.
    2. Results show that CCE1 can mediate intramolecular recombination in human mitochondria, and it is necessary to strictly regulate the expression of CCE1 in human cells to ensure the selection and maintenance of WT mtDNA.
      Title: The yeast Holliday junction resolvase, CCE1, can restore wild-type mitochondrial DNA to human cells carrying rearranged mitochondrial DNA.
    3. The putative recombination genes CCE1, DIN7, and MHR1 have overlapping function with the mismatch repair homolog MSH1 in point mutation avoidance and suppression of aberrant recombination events.
      Title: Overlapping contributions of Msh1p and putative recombination proteins Cce1p, Din7p, and Mhr1p in large-scale recombination and genome sorting events in the mitochondrial genome of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Y-form DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables crossed form four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flap-structured DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial genome maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial genome maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cruciform cutting endonuclease
    NP_012914.1
    • Mitochondrial cruciform cutting endonuclease; cleaves Holliday junctions formed during recombination of mitochondrial DNA; CCE1 has a paralog, MRS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      420155..421216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179577.1 → NP_012914.1  TPA: cruciform cutting endonuclease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012914.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXS5, Q03702
      UniProtKB/TrEMBL
      A6ZZV4, B3LR73, C7GRH0, G2WI20, N1P0R6
      Conserved Domains (1) summary
      cd16963
      Location:22 → 318
      CCE1; fungal mitochondrial Holliday junction resolvases similar to Saccharomyces cerevisiae CCE1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03702.1

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