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    COS5 Cos5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853626, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COS5
    Official Full Name
    Cos5p
    Primary source
    SGD:S000003922
    Locus tag
    YJR161C
    See related
    AllianceGenome:SGD:S000003922; FungiDB:YJR161C; VEuPathDB:YJR161C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in endosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COS5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (742848..743999, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene L-iditol 2-dehydrogenase SOR1 Neighboring gene alpha-glucoside permease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tetraspan cargo adaptors usher GPI-anchored proteins into multivesicular bodies. MacDonald C, et al. Cell Cycle, 2015. PMID 26505929, Free PMC Article
    2. ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. Spode I, et al. J Mol Biol, 2002 May 31. PMID 12051917
    3. An evolutionary scenario for one of the largest yeast gene families. Despons L, et al. Trends Genet, 2006 Jan. PMID 16269202
    4. A family of tetraspans organizes cargo for sorting into multivesicular bodies. MacDonald C, et al. Dev Cell, 2015 May 4. PMID 25942624, Free PMC Article
    5. Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners. O'Connor HF, et al. EMBO Rep, 2015 Dec. PMID 26508657, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cos5p
    NP_012695.3
    • Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      742848..743999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181819.3 → NP_012695.3  TPA: Cos5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012695.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWX9, P47187
      UniProtKB/TrEMBL
      B3LHC2
      Conserved Domains (1) summary
      pfam00674
      Location:74 → 167
      DUP; DUP family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47187.1

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