U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PEF1 Pef1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852949, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PEF1
    Official Full Name
    Pef1p
    Primary source
    SGD:S000003290
    Locus tag
    YGR058W
    See related
    AllianceGenome:SGD:S000003290; FungiDB:YGR058W; VEuPathDB:YGR058W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables calcium ion binding activity and zinc ion binding activity. Involved in axial cellular bud site selection; bipolar cellular bud site selection; and regulation of COPII vesicle coating. Located in cellular bud neck and cytosol. Orthologous to several human genes including PEF1 (penta-EF-hand domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PEF1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (606136..607143)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene RSC subunit protein RSC1 Neighboring gene Lst7p Neighboring gene septin SPR3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The yeast penta-EF protein Pef1p is involved in cation-dependent budding and cell polarization. Vernarecci S, et al. Mol Microbiol, 2007 Aug. PMID 17640275
    2. Involvement of the penta-EF-hand protein Pef1p in the Ca2+-dependent regulation of COPII subunit assembly in Saccharomyces cerevisiae. Yoshibori M, et al. PLoS One, 2012. PMID 22792405, Free PMC Article
    3. Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae. Allan CM, et al. J Biol Chem, 2015 Mar 20. PMID 25631044, Free PMC Article
    4. Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method. Makanae K, et al. Genome Res, 2013 Feb. PMID 23275495, Free PMC Article
    5. Conditional genetic interactions of RTT107, SLX4, and HRQ1 reveal dynamic networks upon DNA damage in S. cerevisiae. Leung GP, et al. G3 (Bethesda), 2014 Apr 2. PMID 24700328, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axial cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bipolar cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of COPII vesicle coating IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of COPII vesicle coating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of COPII vesicle coating IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in site of polarized growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Pef1p
    NP_011572.2
    • Penta-EF-hand protein; required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      606136..607143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181187.2 → NP_011572.2  TPA: Pef1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011572.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUJ3, P53238
      UniProtKB/TrEMBL
      A6ZV43, B3LIG5, B5VJ08, C7GXP1, C8Z8V2, G2WEE5, N1P5R6
      Conserved Domains (1) summary
      cd16180
      Location:161 → 329
      EFh_PEF_Group_I; Penta-EF hand, calcium binding motifs, found in Group I PEF proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53238.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools