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    NAF1 RNA-binding snoRNP assembly protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855599, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NAF1
    Official Full Name
    RNA-binding snoRNP assembly protein
    Primary source
    SGD:S000005068
    Locus tag
    YNL124W
    See related
    AllianceGenome:SGD:S000005068; FungiDB:YNL124W; VEuPathDB:YNL124W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in box H/ACA snoRNP assembly. Located in nucleoplasm. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human NAF1 (nuclear assembly factor 1 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NAF1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (392892..394370)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Spc98p Neighboring gene Esbp6p Neighboring gene Nma111p Neighboring gene mitochondrial 54S ribosomal protein MRP35

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Shq1p.Naf1p complex is required for box H/ACA small nucleolar ribonucleoprotein particle biogenesis. Yang PK, et al. J Biol Chem, 2002 Nov 22. PMID 12228251
    2. The cotranscriptional assembly of snoRNPs controls the biosynthesis of H/ACA snoRNAs in Saccharomyces cerevisiae. Ballarino M, et al. Mol Cell Biol, 2005 Jul. PMID 15964797, Free PMC Article
    3. The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p. Leulliot N, et al. J Mol Biol, 2007 Aug 31. PMID 17612558
    4. Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase. Li S, et al. Genes Dev, 2011 Nov 15. PMID 22085967, Free PMC Article
    5. Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita. Li S, et al. EMBO J, 2011 Nov 25. PMID 22117216, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p
      Title: The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in box H/ACA snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in box H/ACA snoRNP assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in box H/ACA snoRNP assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in box H/ACA snoRNP assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sno(s)RNA-containing ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sno(s)RNA-containing ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding snoRNP assembly protein
    NP_014275.3
    • RNA-binding protein required for the assembly of box H/ACA snoRNPs; thus required for pre-rRNA processing; forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      392892..394370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182962.3 → NP_014275.3  TPA: RNA-binding snoRNP assembly protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014275.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B0KZR2, B0KZS1, B0KZT9, B0KZZ3, B0L002, D6W159, P53919
      UniProtKB/TrEMBL
      C7GKC2, N1NWI9
      Conserved Domains (2) summary
      PRK10263
      Location:343 → 448
      PRK10263; DNA translocase FtsK; Provisional
      pfam04410
      Location:119 → 263
      Gar1; Gar1/Naf1 RNA binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53919.1

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