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    FPY1 Fpy1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855216, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FPY1
    Official Full Name
    Fpy1p
    Primary source
    SGD:S000004790
    Locus tag
    YMR178W
    See related
    AllianceGenome:SGD:S000004790; FungiDB:YMR178W; VEuPathDB:YMR178W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables FAD diphosphatase activity. Involved in flavin-containing compound metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FPY1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (618479..619303)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Ecm5p Neighboring gene Mmt1p Neighboring gene Spt21p Neighboring gene polynucleotide 5'-phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a non-nudix pyrophosphatase points to interplay between flavin and NAD(H) homeostasis in Saccharomyces cerevisiae. Lynch JH, et al. PLoS One, 2018. PMID 29902190, Free PMC Article
    2. Global protein expression profiling of budding yeast in response to DNA damage. Lee MW, et al. Yeast, 2007 Mar. PMID 17351896
    3. A proteomic screen of Ty1 integrase partners identifies the protein kinase CK2 as a regulator of Ty1 retrotransposition. Barkova A, et al. Mob DNA, 2022 Nov 18. PMID 36401307, Free PMC Article
    4. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549
    5. A global S. cerevisiae small ubiquitin-related modifier (SUMO) system interactome. Srikumar T, et al. Mol Syst Biol, 2013 May 28. PMID 23712011, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FAD diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FAD diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in flavin-containing compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flavin-containing compound metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Fpy1p
    NP_013903.1
    • FAD pyrophosphatase; hydrolyzes FAD as the preferred substrate but also acts on NADH and ADP-ribose at lower rates; activity is dependent upon K+ and divalent metal cations; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; FPY1 is not an essential gene; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      618479..619303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182684.1 → NP_013903.1  TPA: Fpy1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013903.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W001, Q03219
      UniProtKB/TrEMBL
      A6ZMN8, B3LM64, B5VPU6, C7GTS3, C8ZF41, G2WKN2, N1NYJ2
      Conserved Domains (1) summary
      COG1058
      Location:3 → 265
      CinA; Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03219.1

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