MSS4 1-phosphatidylinositol-4-phosphate 5-kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MSS4
Official Full Name: 1-phosphatidylinositol-4-phosphate 5-kinase
Primary source: SGD:S000002616
Locus tag: YDR208W
See related: AllianceGenome:SGD:S000002616; FungiDB:YDR208W; VEuPathDB:YDR208W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity; phosphatidylinositol-3-phosphate binding activity; and phosphatidylinositol-4-phosphate binding activity. Involved in ascospore-type prospore assembly and phosphatidylinositol phosphate biosynthetic process. Located in nucleus and plasma membrane. Used to study cancer. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 3. Orthologous to several human genes including PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha); PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase type 1 beta); and PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MSS4 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (868224..870563)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recruitment of the lipid kinase Mss4 to the meiotic spindle pole promotes prospore membrane formation in Saccharomyces cerevisiae.
Title: Recruitment of the lipid kinase Mss4 to the meiotic spindle pole promotes prospore membrane formation in Saccharomyces cerevisiae.
The identified 8-amino acid conserved insert in fungal PIP5K plays an important role in the binding of this protein with membrane surface.
Title: Identification of a conserved 8 aa insert in the PIP5K protein in the Saccharomycetaceae family of fungi and the molecular dynamics simulations and structural analysis to investigate its potential functional role.
Data show the PtdIns 4-kinase Pik1 is involved in Atg9 trafficking through the Golgi and is involved in both nonselective and selective types of autophagy, whereas the PtdIns4P 5-kinase Mss4 is involved in mitophagy but not nonselective autophagy.
Title: Phosphatidylinositol 4-kinases are required for autophagic membrane trafficking.
Findings show that the exocytic signal involves PI delivery Mss4 by Sfh5, generation of PI(4,5)P(2), and PI(4,5)P(2)-dependent regulation of Cdc42 and the actin cytoskeleton.
Title: A phosphatidylinositol-transfer protein and phosphatidylinositol-4-phosphate 5-kinase control Cdc42 to regulate the actin cytoskeleton and secretory pathway in yeast.
We characterized a novel multicopy suppressor gene of ISP-1-mediated cell death in yeast, MSS4. MSS4 encodes a phosphatidylinositol-4-phosphate 5-kinase that synthesizes phosphatidylinositol (4,5)-bisphosphate (PI4,5P(2)).
Title: Disturbance of sphingolipid biosynthesis abrogates the signaling of Mss4, phosphatidylinositol-4-phosphate 5-kinase, in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4-phosphate binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ascospore-type prospore assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 1-phosphatidylinositol-4-phosphate 5-kinase

NP_010494.1

EC 2.7.1.68

Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

868224..870563

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180516.1 → NP_010494.1 TPA: 1-phosphatidylinositol-4-phosphate 5-kinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010494.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSI9, P38994

UniProtKB/TrEMBL

B3LG77, B5VG99, N1PAF5

Conserved Domains (1) summary

COG5253
Location:4 → 772

MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]