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    VNX1 Vnx1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VNX1
    Official Full Name
    Vnx1p
    Primary source
    SGD:S000005265
    Locus tag
    YNL321W
    See related
    AllianceGenome:SGD:S000005265; FungiDB:YNL321W; VEuPathDB:YNL321W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables calcium:proton antiporter activity; potassium:proton antiporter activity; and sodium:proton antiporter activity. Involved in potassium ion transport; proton transmembrane transport; and sodium ion transport. Located in endoplasmic reticulum membrane; fungal-type vacuole membrane; and vacuole-mitochondrion membrane contact site. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VNX1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (34696..37422)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Lem3p Neighboring gene Kre1p Neighboring gene uncharacterized protein Neighboring gene Hxt14p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of a wheat NHX antiporter gene TaNHX2 that encodes a K(+)/H(+) exchanger. Xu Y, et al. PLoS One, 2013. PMID 24223765, Free PMC Article
    2. Identification and characterization of Vnx1p, a novel type of vacuolar monovalent cation/H+ antiporter of Saccharomyces cerevisiae. Cagnac O, et al. J Biol Chem, 2007 Aug 17. PMID 17588950
    3. Paradigm for industrial strain improvement identifies sodium acetate tolerance loci in Zymomonas mobilis and Saccharomyces cerevisiae. Yang S, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20484677, Free PMC Article
    4. Subcellular potassium and sodium distribution in Saccharomyces cerevisiae wild-type and vacuolar mutants. Herrera R, et al. Biochem J, 2013 Sep 15. PMID 23829444
    5. Roles for intracellular cation transporters in respiratory growth of yeast. Zhang F, et al. Metallomics, 2019 Oct 16. PMID 31402362

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the relative importance of Nhx1p, Vnx1p, and Vcx1p in the vacuolar accumulation of monovalent cations
      Title: Vacuolar cation/H+ antiporters of Saccharomyces cerevisiae.
    2. the vacuole-bound Vnx1p appears to play roles in the regulation of ion homeostasis and cellular pH
      Title: Identification and characterization of Vnx1p, a novel type of vacuolar monovalent cation/H+ antiporter of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium:proton antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:proton antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sodium:proton antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole-mitochondrion membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Vnx1p
    NP_014078.1
    • Calcium/H+ antiporter localized to endoplasmic reticulum membrane; member of calcium exchanger (CAX) family; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      34696..37422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183159.1 → NP_014078.1  TPA: Vnx1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014078.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0M5, P42839
      UniProtKB/TrEMBL
      A6ZSG0, C8ZGK4, N1P437
      Conserved Domains (2) summary
      COG0387
      Location:490 → 904
      ChaA; Ca2+/H+ antiporter [Inorganic ion transport and metabolism]
      pfam03733
      Location:239 → 296
      YccF; Inner membrane component domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42839.1

    Gene LinkOut

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