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    MORC3 MORC family CW-type zinc finger 3 [ Homo sapiens (human) ]

    Gene ID: 23515, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MORC3provided by HGNC
    Official Full Name
    MORC family CW-type zinc finger 3provided by HGNC
    Primary source
    HGNC:HGNC:23572
    See related
    Ensembl:ENSG00000159256 MIM:610078; AllianceGenome:HGNC:23572
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NXP2; ZCW5; ZCWCC3
    Summary
    This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in bone marrow (RPKM 15.2), ovary (RPKM 12.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MORC3 in Genome Data Viewer
    Location:
    21q22.12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (36320197..36376632)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (34702785..34759216)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (37692495..37748930)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr21:37668114-37668355 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:37679355-37679926 Neighboring gene serine and arginine rich splicing factor 9 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13284 Neighboring gene ribosomal protein S26 pseudogene 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:37708895-37710094 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:37737075-37737251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37758141-37758642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37758643-37759142 Neighboring gene ATP synthase membrane subunit f pseudogene 1 Neighboring gene chromatin assembly factor 1 subunit B Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:37780832-37782031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37802462-37803337 Neighboring gene CLDN14 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37836794-37837391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37842779-37843278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18436 Neighboring gene claudin 14 Neighboring gene proteasome 26S subunit, non-ATPase 4 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients. Rogers A, et al. Arthritis Care Res (Hoboken), 2017 Dec. PMID 28129490, Free PMC Article
    2. MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies. Champion A, et al. J Med Virol, 2023 Nov. PMID 38009611, Free PMC Article
    3. MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus. Sloan E, et al. J Virol, 2016 Oct 1. PMID 27440897, Free PMC Article
    4. The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains. Kimura Y, et al. J Biol Chem, 2002 Jun 7. PMID 11927593
    5. Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis. Ceribelli A, et al. Arthritis Res Ther, 2012 Apr 30. PMID 22546500, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies.
      Title: MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies.
    2. MORC3 restricts human cytomegalovirus infection by suppressing the major immediate-early promoter activity.
      Title: MORC3 restricts human cytomegalovirus infection by suppressing the major immediate-early promoter activity.
    3. En garde! The duel functions of MORC3.
      Title: En garde! The duel functions of MORC3.
    4. Self-guarding of MORC3 enables virulence factor-triggered immunity.
      Title: Self-guarding of MORC3 enables virulence factor-triggered immunity.
    5. Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation.
      Title: Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation.
    6. Data show that MORC family CW-type zinc finger 3 (MORC3) ATPase is a new target of NS1 protein, influenza A virus (NS1) from H3N2-subtype influenza virus.
      Title: MORC3 Is a Target of the Influenza A Viral Protein NS1.
    7. Mechanism for autoinhibition and activation
      Title: Mechanism for autoinhibition and activation of the MORC3 ATPase.
    8. our studies provide a molecular framework detailing MORC3 functions and suggest that its modulation may contribute to human disease.
      Title: Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
    9. Dermatomyositis patients with anti-NXP-2 antibodies have a distinct and often severe systemic phenotype that includes myalgia, peripheral edema, and significant dysphagia, despite having milder inflammatory skin disease.
      Title: Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients.
    10. MORC3 has antiviral activity during herpes simplex virus 1 and human cytomegalovirus infections.
      Title: MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of protein location in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of protein location in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of interferon-beta production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cellular senescence IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MORC family CW-type zinc finger protein 3
    Names
    nuclear matrix protein 2
    nuclear matrix protein NXP2
    zinc finger CW-type coiled-coil domain protein 3
    zinc finger, CW type with coiled-coil domain 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320445.2 → NP_001307374.1  MORC family CW-type zinc finger protein 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2).
      Source sequence(s)
      AK295133, BC144116, BM786077
      UniProtKB/TrEMBL
      A2RU29, B4DHJ4, Q4VBZ9
      Related
      ENST00000487909.5
      Conserved Domains (4) summary
      COG1196
      Location:602 → 796
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07496
      Location:338 → 375
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:178 → 311
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
      cl00075
      Location:1 → 64
      HATPase; Histidine kinase-like ATPase domain

    2. NM_001320446.2 → NP_001307375.1  MORC family CW-type zinc finger protein 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2).
      Source sequence(s)
      BC144116, BM786077, DA434361
      UniProtKB/TrEMBL
      A2RU29, B4DHJ4, Q4VBZ9
      Conserved Domains (4) summary
      COG1196
      Location:602 → 796
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07496
      Location:338 → 375
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:178 → 311
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
      cl00075
      Location:1 → 64
      HATPase; Histidine kinase-like ATPase domain

    3. NM_015358.3 → NP_056173.1  MORC family CW-type zinc finger protein 3 isoform 1

      See identical proteins and their annotated locations for NP_056173.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      BC094779, D50926, DA702537
      Consensus CDS
      CCDS42924.1
      UniProtKB/Swiss-Prot
      A8KA92, Q14149, Q9UEZ2
      UniProtKB/TrEMBL
      A2RU29, Q4VBZ9
      Related
      ENSP00000383333.1, ENST00000400485.6
      Conserved Domains (3) summary
      pfam07496
      Location:409 → 446
      zf-CW; CW-type Zinc Finger
      pfam16515
      Location:769 → 861
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
      cl00075
      Location:29 → 127
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      36320197..36376632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      34702785..34759216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14149.3 GenPept UniProtKB/Swiss-Prot:Q14149

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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