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    FKBP9 FKBP prolyl isomerase 9 [ Homo sapiens (human) ]

    Gene ID: 11328, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FKBP9provided by HGNC
    Official Full Name
    FKBP prolyl isomerase 9provided by HGNC
    Primary source
    HGNC:HGNC:3725
    See related
    Ensembl:ENSG00000122642 MIM:616257; AllianceGenome:HGNC:3725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FKBP60; FKBP63; PPIase
    Summary
    Predicted to enable calcium ion binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in fat (RPKM 23.7), placenta (RPKM 21.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FKBP9 in Genome Data Viewer
    Location:
    7p14.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (32957440..33006928)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (33097034..33146534)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (32997052..33046540)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RP9 pseudogene Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:32980636-32981524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:32995899-32996849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18084 Neighboring gene ribosomal protein L7a pseudogene 78 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:33018490-33019689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:33038245-33038830 Neighboring gene RNA, U6 small nuclear 388, pseudogene Neighboring gene 5'-nucleotidase, cytosolic IIIA Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18086 Neighboring gene ribosomal protein S29 pseudogene 14 Neighboring gene RNA, 7SL, cytoplasmic 505, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FKBP9 promotes the malignant behavior of glioblastoma cells and confers resistance to endoplasmic reticulum stress inducers. Xu H, et al. J Exp Clin Cancer Res, 2020 Feb 28. PMID 32111229, Free PMC Article
    2. Increasing of FKBP9 can predict poor prognosis in patients with prostate cancer. Jiang FN, et al. Pathol Res Pract, 2020 Jan. PMID 31780055
    3. Biochemical analysis of mouse FKBP60, a novel member of the FKPB family. Shadidy M, et al. Biochim Biophys Acta, 1999 Sep 3. PMID 10524204
    4. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. Patterson CE, et al. Genomics, 2002 Jun. PMID 12036304
    5. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Zhang H, et al. Nat Biotechnol, 2003 Jun. PMID 12754519

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increasing of FKBP9 can predict poor prognosis in patients with prostate cancer.
      Title: Increasing of FKBP9 can predict poor prognosis in patients with prostate cancer.
    2. FKBP9 promotes the malignant behavior of glioblastoma cells and confers resistance to endoplasmic reticulum stress inducers.
      Title: FKBP9 promotes the malignant behavior of glioblastoma cells and confers resistance to endoplasmic reticulum stress inducers.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126772, MGC138258, DKFZp586B1723

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP9
    Names
    63 kDa FK506-binding protein
    63 kDa FKBP
    FK506 binding protein 9, 63 kDa
    FK506-binding protein 9
    FKBP-63
    FKBP-9
    PPIase FKBP9
    rotamase
    NP_001271270.1
    NP_001271272.1
    NP_009201.2
    XP_011513417.1
    XP_047275805.1
    XP_054213155.1
    XP_054213156.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284341.2 → NP_001271270.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001271270.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an additional in-frame coding exon in the 5' region compared to variant 1. The resulting isoform (2) is longer with an internal protein segment not found in isoform 1.
      Source sequence(s)
      AK300328, BC099918, DA234297
      Consensus CDS
      CCDS64622.1
      UniProtKB/TrEMBL
      B3KQQ0
      Related
      ENSP00000439250.1, ENST00000538336.5
      Conserved Domains (3) summary
      cd00051
      Location:550 → 611
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00254
      Location:324 → 415
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:548 → 612
      EF-hand_7; EF-hand domain pair

    2. NM_001284343.2 → NP_001271272.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform 3

      See identical proteins and their annotated locations for NP_001271272.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several exons at the 5' end and contains an alternate 5' terminal exon, which results in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (3) has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC083863, AK293440, BC099918, BQ688269
      Consensus CDS
      CCDS64623.1
      UniProtKB/Swiss-Prot
      O95302
      UniProtKB/TrEMBL
      A7YQ73
      Related
      ENSP00000441317.1, ENST00000490776.3
      Conserved Domains (3) summary
      cd00051
      Location:265 → 326
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00254
      Location:39 → 130
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:263 → 327
      EF-hand_7; EF-hand domain pair

    3. NM_007270.5 → NP_009201.2  peptidyl-prolyl cis-trans isomerase FKBP9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_009201.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
      Source sequence(s)
      BC099918, BC101723, DA234297
      Consensus CDS
      CCDS5439.1
      UniProtKB/Swiss-Prot
      B3KY35, B7Z1G9, B7Z6H3, O95302, Q2M2A1, Q3MIR7, Q6IN76, Q6P2N1, Q96EX5, Q96IJ9
      UniProtKB/TrEMBL
      B3KQQ0
      Related
      ENSP00000242209.4, ENST00000242209.9
      Conserved Domains (2) summary
      cd00051
      Location:497 → 558
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00254
      Location:47 → 138
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      32957440..33006928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515115.4 → XP_011513417.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform X2

      Conserved Domains (1) summary
      pfam00254
      Location:47 → 138
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    2. XM_047419849.1 → XP_047275805.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform X1

      UniProtKB/TrEMBL
      B7Z230

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      33097034..33146534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357181.1 → XP_054213156.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform X2

    2. XM_054357180.1 → XP_054213155.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform X1

      UniProtKB/TrEMBL
      B7Z230
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95302.2 GenPept UniProtKB/Swiss-Prot:O95302

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