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    YSC84 Ysc84p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YSC84
    Official Full Name
    Ysc84p
    Primary source
    SGD:S000001058
    Locus tag
    YHR016C
    See related
    AllianceGenome:SGD:S000001058; FungiDB:YHR016C; VEuPathDB:YHR016C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LSB4
    Summary
    Enables actin filament binding activity. Involved in actin cortical patch localization; actin filament bundle assembly; and endocytosis. Located in actin cortical patch. Orthologous to human SH3YL1 (SH3 and SYLF domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YSC84 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    2
    Sequence:
    Chromosome: VIII; NC_001140.6 (136881..138455, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene tRNA-Gln Neighboring gene Mip6p Neighboring gene Ysc83p Neighboring gene argininosuccinate lyase ARG4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of two divergently transcribed genes centromere-proximal to the ARG4 locus on chromosome VIII of Saccharomyces cerevisiae. Rocco V, et al. Yeast, 1993 Oct. PMID 8256520
    2. Novel proteins linking the actin cytoskeleton to the endocytic machinery in Saccharomyces cerevisiae. Dewar H, et al. Mol Biol Cell, 2002 Oct. PMID 12388763, Free PMC Article
    3. Distinct Actin and Lipid Binding Sites in Ysc84 Are Required during Early Stages of Yeast Endocytosis. Urbanek AN, et al. PLoS One, 2015. PMID 26312755, Free PMC Article
    4. Yeast Arf3p modulates plasma membrane PtdIns(4,5)P2 levels to facilitate endocytosis. Smaczynska-de Rooij II, et al. Traffic, 2008 Apr. PMID 18208507, Free PMC Article
    5. Mechanism of actin capping protein recruitment and turnover during clathrin-mediated endocytosis. Lamb AK, et al. J Cell Biol, 2024 Jan 1. PMID 37966720, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct actin and lipid binding sites in Ysc84 are required during early stages of yeast endocytosis.
      Title: Distinct Actin and Lipid Binding Sites in Ysc84 Are Required during Early Stages of Yeast Endocytosis.
    2. Our analysis suggests a novel role for the SH3 domains of Lsb3p and Lsb4p as hubs that recruit and assemble several endocytic complexes.
      Title: Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins.
    3. polyproline region of Las17 and Ysc84 can promote actin polymerization
      Title: The WASP homologue Las17 activates the novel actin-regulatory activity of Ysc84 to promote endocytosis in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cortical patch localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cortical patch localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin cortical patch localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    Ysc84p
    NP_011880.1
    • Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      136881..138455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179146.1 → NP_011880.1  TPA: Ysc84p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011880.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKW1, P32793
      UniProtKB/TrEMBL
      A6ZSS0, B3LSD7, C8ZA83, N1P1I2
      Conserved Domains (2) summary
      cd11842
      Location:413 → 467
      SH3_Ysc84p_like; Src homology 3 domain of Ysc84p and similar fungal proteins
      COG2930
      Location:1 → 219
      SYLF; Lipid-binding SYLF domain [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32793.2

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