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    DAL7 malate synthase DAL7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854849, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DAL7
    Official Full Name
    malate synthase DAL7
    Primary source
    SGD:S000001470
    Locus tag
    YIR031C
    See related
    AllianceGenome:SGD:S000001470; FungiDB:YIR031C; VEuPathDB:YIR031C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MLS2; MSL2
    Summary
    Enables malate synthase activity. Involved in allantoin catabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DAL7 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (413015..414679, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene allantoicase Neighboring gene Dcg1p Neighboring gene ureidoglycolate hydrolase Neighboring gene Mga2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DAL7 promoter consists of multiple elements that cooperatively mediate regulation of the gene's expression. Yoo HS, et al. Mol Cell Biol, 1989 Aug. PMID 2552287, Free PMC Article
    2. Two structural genes are encoding malate synthase isoenzymes in Saccharomyces cerevisiae. Fernandez E, et al. FEBS Lett, 1993 Apr 12. PMID 8462696
    3. Overlapping positive and negative GATA factor binding sites mediate inducible DAL7 gene expression in Saccharomyces cerevisiae. Rai R, et al. J Biol Chem, 1999 Sep 24. PMID 10488154
    4. Differentially regulated malate synthase genes participate in carbon and nitrogen metabolism of S. cerevisiae. Hartig A, et al. Nucleic Acids Res, 1992 Nov 11. PMID 1454530, Free PMC Article
    5. A novel pathway to produce butanol and isobutanol in Saccharomyces cerevisiae. Branduardi P, et al. Biotechnol Biofuels, 2013 May 4. PMID 23642236, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables malate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables malate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables malate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in allantoin catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glyoxylate cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glyoxylate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    malate synthase DAL7
    NP_012297.3
    • Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      413015..414679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179553.3 → NP_012297.3  TPA: malate synthase DAL7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012297.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVW2, P21826
      UniProtKB/TrEMBL
      A6ZVV1, B3LTH8, C7GLS5, G2WFV9, N1P985
      Conserved Domains (1) summary
      TIGR01344
      Location:31 → 542
      malate_syn_A; malate synthase A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21826.2

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