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    SPC34 Spc34p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853909, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPC34
    Official Full Name
    Spc34p
    Primary source
    SGD:S000001745
    Locus tag
    YKR037C
    See related
    AllianceGenome:SGD:S000001745; FungiDB:YKR037C; VEuPathDB:YKR037C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to microtubule plus-end binding activity. Involved in attachment of spindle microtubules to kinetochore; positive regulation of attachment of spindle microtubules to kinetochore; and positive regulation of microtubule polymerization. Part of DASH complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPC34 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (510910..511797, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Did2p Neighboring gene Caf4p Neighboring gene tRNA N6-adenosine threonylcarbamoyltransferase Neighboring gene tRNA-Asp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Three interacting regions of the Ndc80 and Dam1 complexes support microtubule tip-coupling under load. Flores RL, et al. J Cell Biol, 2022 May 2. PMID 35353161, Free PMC Article
    2. Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins. Meraldi P, et al. Genome Biol, 2006. PMID 16563186, Free PMC Article
    3. Exhaustive identification of interaction domains using a high-throughput method based on two-hybrid screening and PCR-convergence: molecular dissection of a kinetochore subunit Spc34p. Ikeuchi A, et al. Nucleic Acids Res, 2003 Dec 1. PMID 14627828, Free PMC Article
    4. Molecular requirements for the formation of a kinetochore-microtubule interface by Dam1 and Ndc80 complexes. Lampert F, et al. J Cell Biol, 2013 Jan 7. PMID 23277429, Free PMC Article
    5. The Ndc80 complex bridges two Dam1 complex rings. Kim JO, et al. Elife, 2017 Feb 13. PMID 28191870, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in attachment of spindle microtubules to kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DASH complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DASH complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spc34p
    NP_012963.3
    • Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      510910..511797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179827.3 → NP_012963.3  TPA: Spc34p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012963.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXA0, P36131
      UniProtKB/TrEMBL
      A6ZZZ9, B3LRB8, B5VMI5, C7GNM5, C8ZCK2, G2WI67, N1P0X0
      Conserved Domains (1) summary
      pfam08657
      Location:5 → 293
      DASH_Spc34; DASH complex subunit Spc34
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36131.1

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