sbds.S SBDS ribosome assembly guanine nucleotide exchange factor S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: sbds.S
Official Full Name: SBDS ribosome assembly guanine nucleotide exchange factor S homeolog
Primary source: Xenbase:XB-GENE-1003512
Locus tag: XELAEV_18015375mg
See related: EnsemblRapid:ENSXLAG00005003747 AllianceGenome:Xenbase:XB-GENE-1003512
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: sbds
Summary: Predicted to enable ribosome binding activity. Predicted to act upstream of or within cytosolic ribosome assembly and hematopoietic progenitor cell differentiation. Predicted to be located in spindle pole. Human ortholog(s) of this gene implicated in Shwachman-Diamond syndrome and aplastic anemia. Orthologous to human SBDS (SBDS ribosome maturation factor). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 2S

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (89890578..89897575, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (80883921..80890966, complement)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytosolic ribosome assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytosolic ribosome assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ribosome maturation protein SBDS

Names: SBDS, ribosome maturation factorS homeolog; Shwachman-Bodian-Diamond syndrome S homeolog; shwachman-Bodian-Diamond syndrome protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098689.1 → NP_001092159.1 ribosome maturation protein SBDS

See identical proteins and their annotated locations for NP_001092159.1

Status: PROVISIONAL

Source sequence(s)

BC141736

UniProtKB/Swiss-Prot

A5D8M6

UniProtKB/TrEMBL

A0A974DHW0

Related

ENSXLAP00005011175.1, ENSXLAT00005011350.1

Conserved Domains (3) summary

COG1500
Location:9 → 241

Sdo1; Ribosome maturation protein Sdo1 [Translation, ribosomal structure and biogenesis]

pfam01172
Location:17 → 98

SBDS; Shwachman-Bodian-Diamond syndrome (SBDS) protein

pfam09377
Location:107 → 224

SBDS_C; SBDS protein C-terminal domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

89890578..89897575 complement

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GenBank, FASTA, Sequence Viewer (Graphics)