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    pou5f3.3.L POU class 5 homeobox 3, gene 3 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 397936, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pou5f3.3.L
    Official Full Name
    POU class 5 homeobox 3, gene 3 L homeolog
    Primary source
    Xenbase:XB-GENE-5903594
    Locus tag
    XELAEV_18038230mg
    See related
    EnsemblRapid:ENSXLAG00005018663 AllianceGenome:Xenbase:XB-GENE-5903594
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    oct60; pou60; oct-60; xoct60; XLPOU60; XOct-60; XLPOU-60; pou5f1.3; pou5f3.3
    Summary
    Enables DNA-binding transcription factor binding activity; RNA binding activity; and transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; negative regulation of activin receptor signaling pathway; and post-anal tail morphogenesis. Part of transcription regulator complex. Is expressed in ectoderm and genital system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pou5f3.3.L in Genome Data Viewer
    Location:
    chromosome: 8L
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (2287556..2293268, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (2129670..2135492, complement)

    Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 2 L homeolog Neighboring gene fucosyltransferase 7 (alpha (1,3) fucosyltransferase) L homeolog Neighboring gene POU class 5 homeobox 3, gene 2 L homeolog Neighboring gene POU class 5 homeobox 3, gene 1 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pou5f3.3 is involved in establishment and maintenance of hematopoietic cells during Xenopus development. Ezawa M, et al. Tissue Cell, 2021 Oct. PMID 33798831
    2. XLPOU-60, a Xenopus POU-domain mRNA, is oocyte-specific from very early stages of oogenesis, and localised to presumptive mesoderm and ectoderm in the blastula. Whitfield T, et al. Dev Biol, 1993 Feb. PMID 8432392
    3. Xenopus interspersed RNA families, Ocr and XR, bind DNA-binding proteins. Guttridge KL, et al. Zygote, 1995 May. PMID 7582913
    4. Expression of pluripotency factors in larval epithelia of the frog Xenopus: evidence for the presence of cornea epithelial stem cells. Perry KJ, et al. Dev Biol, 2013 Feb 15. PMID 23274420, Free PMC Article
    5. Spalt-like 4 promotes posterior neural fates via repression of pou5f3 family members in Xenopus. Young JJ, et al. Development, 2014 Apr. PMID 24715458, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pou5f3.3 is involved in establishment and maintenance of hematopoietic cells during Xenopus development.
      Title: Pou5f3.3 is involved in establishment and maintenance of hematopoietic cells during Xenopus development.
    2. These results suggest that Sall4, activated by posteriorizing signals, represses the pou5f3 genes to provide a permissive environment.
      Title: Spalt-like 4 promotes posterior neural fates via repression of pou5f3 family members in Xenopus.
    3. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
      Title: Expression of pluripotency factors in larval epithelia of the frog Xenopus: evidence for the presence of cornea epithelial stem cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within head development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of activin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural tube formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-anal tail morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    POU class 5 homeobox 3, gene 3
    Names
    POU class 5 homeobox 1, gene 3
    POU domain, class 5, transcription factor 1.3
    POU-domain protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001088114.1 → NP_001081583.1  POU class 5 homeobox 3, gene 3

      See identical proteins and their annotated locations for NP_001081583.1

      Status: PROVISIONAL

      Source sequence(s)
      BC070557
      UniProtKB/Swiss-Prot
      Q03916, Q91989
      UniProtKB/TrEMBL
      A0A974H6R3
      Related
      ENSXLAP00005055130.1, ENSXLAT00005056328.1
      Conserved Domains (2) summary
      pfam00046
      Location:300 → 352
      Homeobox; Homeobox domain
      pfam00157
      Location:208 → 276
      Pou; Pou domain - N-terminal to homeobox domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      2287556..2293268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91989.1 GenPept UniProtKB/Swiss-Prot:Q91989

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials