Car1 carbonic anhydrase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Car1provided by MGI
Official Full Name: carbonic anhydrase 1provided by MGI
Primary source: MGI:MGI:88268
See related: Ensembl:ENSMUSG00000027556 AllianceGenome:MGI:88268
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ca1; Car-1
Summary: Predicted to enable arylesterase activity; carbonate dehydratase activity; and cyanamide hydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and skeleton. Orthologous to human CA1 (carbonic anhydrase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward colon adult (RPKM 847.4) See more
Orthologs: human all
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Genomic context

Location:: 3 A1; 3 3.18 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (14831274..14873425, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (14766214..14808365, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of carbonic anhydrase 1 beneficial for depressive disorder.
Title: Upregulation of carbonic anhydrase 1 beneficial for depressive disorder.
During inner ear development, transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were expressed at higher levels than other isozymes.
Title: A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development.
Over-expression of CA1 may aggravate joint inflammation and tissue destruction in the transgenic mice.
Title: Transgenic mice over-expressing carbonic anhydrase I showed aggravated joint inflammation and tissue destruction.
Taken together, these data show that Ldb1 forms a regulatory complex to maintain Car1 expression in erythroid cells.
Title: Ldb1 regulates carbonic anhydrase 1 during erythroid differentiation.
Regulatory dendritic cells pulsed with carbonic anhydrase I suppress development of colitis in a severe combined immunodeficiency (SCID) mouse transfer model by inducing the differentiation of regulatory T cells in an antigen-specific manner.
Title: Regulatory dendritic cells pulsed with carbonic anhydrase I protect mice from colitis induced by CD4+CD25- T cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M32452 (e-PCR)
- UniSTS:178808

D3Mit237 (e-PCR), detects polymorphism
- UniSTS:129657

Car1 (e-PCR), detects polymorphism
- UniSTS:506764

AW555628 (e-PCR)
- UniSTS:185525

NoName (e-PCR)
- UniSTS:487408

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arylesterase activity	IEA Inferred from Electronic Annotation more info
enables arylesterase activity	ISO Inferred from Sequence Orthology more info
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	ISO Inferred from Sequence Orthology more info
enables carbonate dehydratase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cyanamide hydratase activity	ISO Inferred from Sequence Orthology more info
enables cyanamide hydratase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydro-lyase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carbonic anhydrase 1

Names: CA-I; carbonate dehydratase I; carbonic anhydrase I; cyanamide hydratase CA1

NP_001077426.1

EC 4.2.1.1

EC 4.2.1.69

NP_033929.2

EC 4.2.1.1

EC 4.2.1.69

XP_011246439.1

EC 4.2.1.1

EC 4.2.1.69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083957.1 → NP_001077426.1 carbonic anhydrase 1

See identical proteins and their annotated locations for NP_001077426.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has a different 5' UTR compared to transcript variant 1. Both transcript variants (1 and 2) encode the same protein. This variant represents use of an alternate downstream promoter and results in colon epithelia cell expression.

Source sequence(s)

AK162331, AV374892

Consensus CDS

CCDS17248.1

UniProtKB/Swiss-Prot

P13634, Q3TS19, Q9DC84

Related

ENSMUSP00000091925.5, ENSMUST00000094365.11

Conserved Domains (1) summary

cl00012
Location:2 → 261

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
NM_009799.4 → NP_033929.2 carbonic anhydrase 1

See identical proteins and their annotated locations for NP_033929.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both transcript variants (1 and 2) encode the same protein. This variant represents use of an upstream long terminal repeat (LTR) promoter and exon sequence, and results in erythroid expression. (PMID: 2571923)

Source sequence(s)

AK003066, AK162331, AV374892, BB842334

Consensus CDS

CCDS17248.1

UniProtKB/Swiss-Prot

P13634, Q3TS19, Q9DC84

Related

ENSMUSP00000137926.2, ENSMUST00000181860.8

Conserved Domains (1) summary

cl00012
Location:2 → 261

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

14831274..14873425 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248137.1 → XP_011246439.1 carbonic anhydrase 1 isoform X1

See identical proteins and their annotated locations for XP_011246439.1

UniProtKB/Swiss-Prot

P13634, Q3TS19, Q9DC84

Conserved Domains (1) summary

cl00012
Location:2 → 261

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...