Slc47a1 solute carrier family 47, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc47a1provided by MGI
Official Full Name: solute carrier family 47, member 1provided by MGI
Primary source: MGI:MGI:1914723
See related: Ensembl:ENSMUSG00000010122 AllianceGenome:MGI:1914723
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MATE1; mMATE1; 1300013J15Rik
Summary: Enables polyspecific organic cation:proton antiporter activity. Involved in monoatomic cation transmembrane transport and xenobiotic transmembrane transport. Located in plasma membrane. Is expressed in several structures, including liver; lung; metanephros; nervous system; and spleen. Orthologous to several human genes including SLC47A1 (solute carrier family 47 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 97.2), liver adult (RPKM 32.0) and 3 other tissues See more
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Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (61234226..61269668, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (61343400..61378842, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity.
Title: MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity.
The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis.
Title: The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis.
Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families.
Title: Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families.
Tissue concentration based investigations using [(11)C]metformin by PET enables the functional analysis of MATEs in the liver and kidneys
Title: Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [(11)C]Metformin in Mouse.
Mate1 mRNA expression was decreased in mice with either the ob/ob model or the methionine/choline deficiency model of nonalcoholic steatohepatitis.
Title: Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis.
MATE1 was highly expressed in peroxisomes and the endoplasmic reticulum as well as in plasma membranes in the liver and intestine.
Title: Multidrug and toxic compound extrusion protein-1 (MATE1/SLC47A1) is a novel flavonoid transporter.
[(11)C]Metformin may be useful as a PET probe to non-invasively study the in vivo function of hepatobiliary transport and drug-drug interactions, mediated by MATE1 in future clinical investigations.
Title: The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo.
Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein.
Title: Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein.
Homozygous MATE1 variant could be one of the risk factors for metformin-induced lactic acidosis.
Title: Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis.
MATE1 mediates the efflux of cisplatin and is involved in cisplatin-induced nephrotoxicity.
Title: Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1)
Targeted (3) 1 citation

General gene information

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Markers

AI036982 (e-PCR)
- UniSTS:165762

1300013J15Rik (e-PCR), detects polymorphism
- UniSTS:256648

Slc47a1 (e-PCR), detects polymorphism
- UniSTS:546012

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-arginine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic cation transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables polyspecific organic cation:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables polyspecific organic cation:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables putrescine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables putrescine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables thiamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thiamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables xenobiotic transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-arginine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-arginine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in organic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in organic cation transport	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in putrescine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in thiamine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: multidrug and toxin extrusion protein 1

Names: MATE-1; mMATE-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026183.5 → NP_080459.2 multidrug and toxin extrusion protein 1

See identical proteins and their annotated locations for NP_080459.2

Status: VALIDATED

Source sequence(s)

AK009038, BB556514, BB661673, BY006577

Consensus CDS

CCDS24811.2

UniProtKB/Swiss-Prot

Q5SS45, Q8K0H1, Q9CQ64

Related

ENSMUSP00000010267.4, ENSMUST00000010267.10

Conserved Domains (1) summary

cd13132
Location:34 → 468

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

61234226..61269668 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011249188.3 → XP_011247490.1 multidrug and toxin extrusion protein 1 isoform X2

Conserved Domains (1) summary

cd13132
Location:1 → 418

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
XM_006533993.2 → XP_006534056.1 multidrug and toxin extrusion protein 1 isoform X1

Conserved Domains (1) summary

cd13132
Location:70 → 492

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
XM_036156909.1 → XP_036012802.1 multidrug and toxin extrusion protein 1 isoform X4

Conserved Domains (1) summary

cd13132
Location:22 → 308

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
XM_036156910.1 → XP_036012803.1 multidrug and toxin extrusion protein 1 isoform X4

Conserved Domains (1) summary

cd13132
Location:22 → 308

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
XM_011249189.4 → XP_011247491.1 multidrug and toxin extrusion protein 1 isoform X3

See identical proteins and their annotated locations for XP_011247491.1

UniProtKB/Swiss-Prot

Q8K0H1

Conserved Domains (1) summary

cd13132
Location:40 → 326

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
XM_006533995.4 → XP_006534058.1 multidrug and toxin extrusion protein 1 isoform X5

Conserved Domains (1) summary

cd13132
Location:1 → 280

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family