Snrpb small nuclear ribonucleoprotein B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snrpbprovided by MGI
Official Full Name: small nuclear ribonucleoprotein Bprovided by MGI
Primary source: MGI:MGI:98342
See related: Ensembl:ENSMUSG00000027404 AllianceGenome:MGI:98342
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SMB; SM-B; SM11; SNRNP-B
Summary: Enables histone pre-mRNA DCP binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to act upstream of or within protein methylation. Located in cytoplasm and nucleus. Part of histone pre-mRNA 3'end processing complex. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Used to study cerebrocostomandibular syndrome. Human ortholog(s) of this gene implicated in cerebrocostomandibular syndrome and mixed connective tissue disease. Orthologous to human SNRPB (small nuclear ribonucleoprotein polypeptides B and B1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 137.1), adrenal adult (RPKM 133.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 63.19 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (130013560..130031184, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (130171636..130179382, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Non-ubiquitous expression of core spliceosomal protein SmB/B' in chick and mouse embryos.
Title: Non-ubiquitous expression of core spliceosomal protein SmB/B' in chick and mouse embryos.
Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis.
Title: Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis.
SNRPB is a mediator for cellular response to cisplatin in non-small-cell lung cancer.
Title: SNRPB is a mediator for cellular response to cisplatin in non-small-cell lung cancer.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125534 (e-PCR)
- UniSTS:162350

RH136496 (e-PCR)
- UniSTS:210479

MARC_5069-5070:996690109:1 (e-PCR)
- UniSTS:269448

MARC_5181-5182:966894595:1 (e-PCR)
- UniSTS:269463

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables U1 snRNP binding	IEA Inferred from Electronic Annotation more info
enables U1 snRNP binding	ISO Inferred from Sequence Orthology more info
enables U2 snRNP binding	IEA Inferred from Electronic Annotation more info
enables U2 snRNP binding	ISO Inferred from Sequence Orthology more info
enables histone pre-mRNA DCP binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables snRNP binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomerase RNA binding	IEA Inferred from Electronic Annotation more info
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein methylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in spliceosomal snRNP assembly	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal snRNP assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SMN-Sm protein complex	ISO Inferred from Sequence Orthology more info
part_of SMN-Sm protein complex	ISS Inferred from Sequence or Structural Similarity more info
part_of U1 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U1 snRNP	ISO Inferred from Sequence Orthology more info
part_of U1 snRNP	ISS Inferred from Sequence or Structural Similarity more info
part_of U12-type spliceosomal complex	IEA Inferred from Electronic Annotation more info
part_of U12-type spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of U2 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U2 snRNP	IEA Inferred from Electronic Annotation more info
part_of U2 snRNP	ISO Inferred from Sequence Orthology more info
part_of U2-type catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
part_of U2-type catalytic step 2 spliceosome	ISS Inferred from Sequence or Structural Similarity more info
part_of U2-type precatalytic spliceosome	ISO Inferred from Sequence Orthology more info
part_of U2-type precatalytic spliceosome	ISS Inferred from Sequence or Structural Similarity more info
part_of U2-type prespliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of U2-type spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info
part_of U4 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U4 snRNP	ISO Inferred from Sequence Orthology more info
part_of U4 snRNP	ISS Inferred from Sequence or Structural Similarity more info
part_of U4/U6 x U5 tri-snRNP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U4/U6 x U5 tri-snRNP complex	ISO Inferred from Sequence Orthology more info
part_of U4/U6 x U5 tri-snRNP complex	ISS Inferred from Sequence or Structural Similarity more info
part_of U5 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U7 snRNP	ISO Inferred from Sequence Orthology more info
part_of U7 snRNP	ISS Inferred from Sequence or Structural Similarity more info
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
part_of histone pre-mRNA 3'end processing complex	IDA Inferred from Direct Assay more info	PubMed
part_of methylosome	ISO Inferred from Sequence Orthology more info
part_of methylosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of telomerase holoenzyme complex	IEA Inferred from Electronic Annotation more info
part_of telomerase holoenzyme complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: small nuclear ribonucleoprotein-associated protein B

Names: sm protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412650.1 → NP_001399579.1 small nuclear ribonucleoprotein-associated protein B isoform 2

Status: VALIDATED

Source sequence(s)

AL833804
NM_001412651.1 → NP_001399580.1 small nuclear ribonucleoprotein-associated protein B isoform 3

Status: VALIDATED

Source sequence(s)

AL833804
NM_001412652.1 → NP_001399581.1 small nuclear ribonucleoprotein-associated protein B isoform 4

Status: VALIDATED

Source sequence(s)

AL833804
NM_001412653.1 → NP_001399582.1 small nuclear ribonucleoprotein-associated protein B isoform 5

Status: VALIDATED

Source sequence(s)

AL833804

UniProtKB/TrEMBL

O70499
NM_001412654.1 → NP_001399583.1 small nuclear ribonucleoprotein-associated protein B isoform 5

Status: VALIDATED

Source sequence(s)

AL833804

UniProtKB/TrEMBL

O70499
NM_001412655.1 → NP_001399584.1 small nuclear ribonucleoprotein-associated protein B isoform 6

Status: VALIDATED

Source sequence(s)

AL833804

UniProtKB/TrEMBL

O70499
NM_001412656.1 → NP_001399585.1 small nuclear ribonucleoprotein-associated protein B isoform 7

Status: VALIDATED

Source sequence(s)

AL833804

UniProtKB/TrEMBL

O70499
NM_001412657.1 → NP_001399586.1 small nuclear ribonucleoprotein-associated protein B isoform 10

Status: VALIDATED

Source sequence(s)

AL833804

UniProtKB/TrEMBL

O70499
NM_001412658.1 → NP_001399587.1 small nuclear ribonucleoprotein-associated protein B isoform 8

Status: VALIDATED

Source sequence(s)

AL833804
NM_001412659.1 → NP_001399588.1 small nuclear ribonucleoprotein-associated protein B isoform 9

Status: VALIDATED

Source sequence(s)

AL833804
NM_001420982.1 → NP_001407911.1 small nuclear ribonucleoprotein-associated protein B isoform 9

Status: VALIDATED

Source sequence(s)

AL833804
NM_009225.3 → NP_033251.1 small nuclear ribonucleoprotein-associated protein B isoform 1

See identical proteins and their annotated locations for NP_033251.1

Status: VALIDATED

Source sequence(s)

AL833804

Consensus CDS

CCDS16735.1

UniProtKB/Swiss-Prot

P27048, Q3UJT1

UniProtKB/TrEMBL

O70499

Related

ENSMUSP00000099488.5, ENSMUST00000103199.9

Conserved Domains (1) summary

cd01717
Location:5 → 83

Sm_B; Sm protein B

RNA

NR_182019.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL833804
NR_182020.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL833804

Related

ENSMUST00000147570.3
NR_182021.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL833804

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

130013560..130031184 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159932.1 → XP_036015825.1 small nuclear ribonucleoprotein-associated protein B isoform X1

UniProtKB/Swiss-Prot

P27048, Q3UJT1

UniProtKB/TrEMBL

O70499

Conserved Domains (1) summary

cd01717
Location:5 → 83

Sm_B; Sm protein B