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    Loricrin loricrin cornified envelope precursor protein [ Mus musculus (house mouse) ]

    Gene ID: 16939, updated on 9-Dec-2024

    Summary

    Official Symbol
    Loricrinprovided by MGI
    Official Full Name
    loricrin cornified envelope precursor proteinprovided by MGI
    Primary source
    MGI:MGI:96816
    See related
    Ensembl:ENSMUSG00000043165 AllianceGenome:MGI:96816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lor
    Summary
    A structural constituent of cytoskeleton and structural constituent of skin epidermis. Predicted to be involved in keratinocyte differentiation and peptide cross-linking. Located in cytoplasmic side of plasma membrane. Is active in cornified envelope. Is expressed in several structures, including alimentary system; male reproductive system; sensory organ; skin; and thymus. Orthologous to human LORICRIN (loricrin cornified envelope precursor protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward stomach adult (RPKM 762.9) See more
    Orthologs
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    Genomic context

    See Loricrin in Genome Data Viewer
    Location:
    3 F1; 3 40.14 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (91987578..91990447, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (92080271..92083142, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene peptidoglycan recognition protein 3 Neighboring gene STARR-seq mESC enhancer starr_08309 Neighboring gene macrophage migration inhibitory factor, pseudogene 3 Neighboring gene proline rich 9 Neighboring gene late cornified envelope-like proline-rich 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cornified envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cornified envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008508.3NP_032534.2  loricrin

      See identical proteins and their annotated locations for NP_032534.2

      Status: VALIDATED

      Source sequence(s)
      AC163215
      Consensus CDS
      CCDS17546.1
      UniProtKB/Swiss-Prot
      P18165, Q8R0I9
      Related
      ENSMUSP00000052128.7, ENSMUST00000058150.8
      Conserved Domains (1) summary
      pfam15847
      Location:467486
      Loricrin; Major keratinocyte cell envelope protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      91987578..91990447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)