U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dhx58 DExH-box helicase 58 [ Mus musculus (house mouse) ]

    Gene ID: 80861, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dhx58provided by MGI
    Official Full Name
    DExH-box helicase 58provided by MGI
    Primary source
    MGI:MGI:1931560
    See related
    Ensembl:ENSMUSG00000017830 AllianceGenome:MGI:1931560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LPG2; Lgp2; RLR-3; D11Lgp2e; B430001I08Rik
    Summary
    Enables double-stranded RNA binding activity. Involved in regulation of innate immune response; regulation of type I interferon production; and response to virus. Acts upstream of or within response to bacterium. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DHX58 (DExH-box helicase 58). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 14.6), testis adult (RPKM 12.3) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dhx58 in Genome Data Viewer
    Location:
    11 D; 11 63.52 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100585710..100595165, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100694884..100704271, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene STARR-positive B cell enhancer ABC_E7061 Neighboring gene STARR-positive B cell enhancer ABC_E2369 Neighboring gene STARR-positive B cell enhancer ABC_E7062 Neighboring gene NFKB inhibitor interacting Ras-like protein 2 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 11 C17orf113 homolog Neighboring gene predicted gene, 38483 Neighboring gene STARR-positive B cell enhancer ABC_E7063 Neighboring gene STARR-positive B cell enhancer ABC_E9843 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100575167-100575276 Neighboring gene K(lysine) acetyltransferase 2A Neighboring gene heat shock protein, alpha-crystallin-related, B9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic pattern recognition receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic pattern recognition receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of MDA-5 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of MDA-5 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of RIG-I signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of RIG-I signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type I interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MDA-5 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of RIG-I signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of type I interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DHX58
    Names
    ATP-dependent helicase LGP2
    DEXH (Asp-Glu-X-His) box polypeptide 58
    RIG-I-like receptor 3
    RIG-I-like receptor Lgp2
    RLR
    RNA helicase LGP2
    probable ATP-dependent RNA helicase DHX58
    probable ATP-dependent helicase LGP2
    protein D11Lgp2
    NP_084426.2
    XP_036012999.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030150.2NP_084426.2  ATP-dependent RNA helicase DHX58

      See identical proteins and their annotated locations for NP_084426.2

      Status: VALIDATED

      Source sequence(s)
      AF316999, BP766331, BY727457
      Consensus CDS
      CCDS25431.1
      UniProtKB/Swiss-Prot
      A2A5E9, Q99J87, Q9D1X4
      UniProtKB/TrEMBL
      Q3U606
      Related
      ENSMUSP00000017974.7, ENSMUST00000017974.13
      Conserved Domains (5) summary
      COG1111
      Location:2550
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd15806
      Location:552664
      LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
      cd12090
      Location:227345
      MDA5_ID; Insert domain of MDA5
      pfam00271
      Location:350475
      Helicase_C; Helicase conserved C-terminal domain
      pfam04851
      Location:1170
      ResIII; Type III restriction enzyme, res subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100585710..100595165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157106.1XP_036012999.1  ATP-dependent RNA helicase DHX58 isoform X1

      UniProtKB/TrEMBL
      Q3U606
      Conserved Domains (4) summary
      COG1111
      Location:53481
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd15806
      Location:483595
      LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
      cd18802
      Location:280414
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cl28899
      Location:1131
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily