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    Gykl1 glycerol kinase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 14625, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gykl1provided by MGI
    Official Full Name
    glycerol kinase-like 1provided by MGI
    Primary source
    MGI:MGI:891990
    See related
    Ensembl:ENSMUSG00000053624 AllianceGenome:MGI:891990
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gk-rs1
    Summary
    Predicted to enable glycerol kinase activity. Predicted to be involved in glycerol metabolic process; glycerol-3-phosphate biosynthetic process; and triglyceride metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to human GK (glycerol kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Gykl1 in Genome Data Viewer
    Location:
    18 D1; 18 28.25 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (52826751..52828665)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (52693679..52695593)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 474 Neighboring gene RIKEN cDNA 1700034E13 gene Neighboring gene predicted gene, 41725 Neighboring gene synuclein, alpha interacting protein (synphilin) Neighboring gene predicted gene, 50457

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis. Shimada K, et al. J Reprod Dev, 2019 Apr 12. PMID 30662012, Free PMC Article
    2. Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility. Chen Y, et al. Cell Discov, 2017. PMID 28852571, Free PMC Article
    3. Sequence analysis, identification of evolutionary conserved motifs and expression analysis of murine tcof1 provide further evidence for a potential function for the gene and its human homologue, TCOF1. Dixon J, et al. Hum Mol Genet, 1997 May. PMID 9158147
    4. Mouse TCOF1 is expressed widely, has motifs conserved in nucleolar phosphoproteins, and maps to chromosome 18. Paznekas WA, et al. Biochem Biophys Res Commun, 1997 Sep 8. PMID 9299440
    5. Retrotransposition of glycerol kinase-related genes from the X chromosome to autosomes: functional and evolutionary aspects. Pan Y, et al. Genomics, 1999 Aug 1. PMID 10444329

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141317

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol-3-phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycerol kinase-like 1
    Names
    glucokinase activity, related sequence 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010293.3 → NP_034423.2  glycerol kinase-like 1

      See identical proteins and their annotated locations for NP_034423.2

      Status: VALIDATED

      Source sequence(s)
      AC121943, AK076631
      Consensus CDS
      CCDS29250.1
      UniProtKB/TrEMBL
      Q0VDQ2, Q8C635
      Related
      ENSMUSP00000067598.4, ENSMUST00000066193.5
      Conserved Domains (2) summary
      cd07792
      Location:11 → 513
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11 → 513
      glycerol_kin; glycerol kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      52826751..52828665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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