Tnrc6c trinucleotide repeat containing 6C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnrc6cprovided by MGI
Official Full Name: trinucleotide repeat containing 6Cprovided by MGI
Primary source: MGI:MGI:2443265
See related: Ensembl:ENSMUSG00000025571 AllianceGenome:MGI:2443265
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1582; 9930033H14Rik
Summary: Predicted to enable RNA binding activity. Acts upstream of or within several processes, including endoderm formation; lung saccule development; and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Is expressed in central nervous system; lung; and sensory organ. Orthologous to human TNRC6C (trinucleotide repeat containing adaptor 6C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 16.4), whole brain E14.5 (RPKM 14.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 82.96 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (117544529..117654265)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (117653703..117763439)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results imply a complex and indirect mode of regulation of sacculation by TNRC6c, mediated in part by dynamic transcriptional repression of an inhibitor of TGFbeta family gene expression.
Title: Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Tnrc6c (e-PCR), detects polymorphism
- UniSTS:479140

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung saccule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in miRNA-mediated post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of miRNA-mediated gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: trinucleotide repeat-containing gene 6C protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395514.1 → NP_001382443.1 trinucleotide repeat-containing gene 6C protein isoform 1

Status: VALIDATED

Source sequence(s)

AL645856, AL672228

UniProtKB/TrEMBL

B1ATC3, B7ZC94

Related

ENSMUSP00000101951.2, ENSMUST00000106344.8

Conserved Domains (6) summary

cd14283
Location:1146 → 1183

UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins

pfam10427
Location:1034 → 1149

Ago_hook; Argonaute hook

pfam12938
Location:1234 → 1424

M_domain; M domain of GW182

pfam16608
Location:1468 → 1722

TNRC6-PABC_bdg; TNRC6-PABC binding domain

cd12713
Location:1718 → 1805

RRM_TNRC6C; RNA recognition motif (RRM) found in vertebrate trinucleotide repeat-containing gene 6C protein (TNRC6C)

NF033849
Location:446 → 630

ser_rich_anae_1; serine-rich protein
NM_001395515.1 → NP_001382444.1 trinucleotide repeat-containing gene 6C protein isoform 2

Status: VALIDATED

Source sequence(s)

AL645856, AL672228

UniProtKB/TrEMBL

B7ZC94

Conserved Domains (4) summary

smart00360
Location:1718 → 1781

RRM; RNA recognition motif

cd14283
Location:1146 → 1183

UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins

pfam10427
Location:1034 → 1149

Ago_hook; Argonaute hook

pfam12938
Location:1225 → 1416

M_domain; M domain of GW182
NM_198022.2 → NP_932139.2 trinucleotide repeat-containing gene 6C protein isoform 1

See identical proteins and their annotated locations for NP_932139.2

Status: VALIDATED

Source sequence(s)

AI844481, AK122529, AK147551, CJ099743, CJ103032

Consensus CDS

CCDS36381.1

UniProtKB/TrEMBL

B1ATC3, B7ZC94

Related

ENSMUSP00000026658.7, ENSMUST00000026658.13

Conserved Domains (6) summary

cd14283
Location:1146 → 1183

UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins

pfam10427
Location:1034 → 1149

Ago_hook; Argonaute hook

pfam12938
Location:1234 → 1424

M_domain; M domain of GW182

pfam16608
Location:1468 → 1722

TNRC6-PABC_bdg; TNRC6-PABC binding domain

cd12713
Location:1718 → 1805

RRM_TNRC6C; RNA recognition motif (RRM) found in vertebrate trinucleotide repeat-containing gene 6C protein (TNRC6C)

NF033849
Location:446 → 630

ser_rich_anae_1; serine-rich protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

117544529..117654265

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245905.1 → XP_030101765.1 trinucleotide repeat-containing gene 6C protein isoform X1

UniProtKB/TrEMBL

B7ZC94

Conserved Domains (5) summary

cd12713
Location:1759 → 1841

RRM_TNRC6C; RNA recognition motif in vertebrate trinucleotide repeat-containing gene 6C protein (TNRC6C)

cd14283
Location:1182 → 1219

UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins

pfam10427
Location:1070 → 1185

Ago_hook; Argonaute hook

pfam12938
Location:1270 → 1460

M_domain; M domain of GW182

pfam16608
Location:1504 → 1758

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_006533111.4 → XP_006533174.2 trinucleotide repeat-containing gene 6C protein isoform X5

UniProtKB/TrEMBL

B7ZC94

Conserved Domains (5) summary

cd12713
Location:1695 → 1777

RRM_TNRC6C; RNA recognition motif in vertebrate trinucleotide repeat-containing gene 6C protein (TNRC6C)

cd14283
Location:1182 → 1219

UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins

pfam10427
Location:1070 → 1185

Ago_hook; Argonaute hook

pfam12938
Location:1270 → 1460

M_domain; M domain of GW182

pfam16608
Location:1504 → 1694

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_006533109.4 → XP_006533172.2 trinucleotide repeat-containing gene 6C protein isoform X2

UniProtKB/TrEMBL

B7ZC94

Conserved Domains (5) summary

cd12713
Location:1751 → 1833

RRM_TNRC6C; RNA recognition motif in vertebrate trinucleotide repeat-containing gene 6C protein (TNRC6C)

cd14283
Location:1182 → 1219

UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins

pfam10427
Location:1070 → 1185

Ago_hook; Argonaute hook

pfam12938
Location:1261 → 1452

M_domain; M domain of GW182

pfam16608
Location:1496 → 1750

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_036156616.1 → XP_036012509.1 trinucleotide repeat-containing gene 6C protein isoform X7

UniProtKB/TrEMBL

B7ZC94

Conserved Domains (6) summary

cd14283
Location:1182 → 1219

UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins

pfam10427
Location:1070 → 1185

Ago_hook; Argonaute hook

pfam12938
Location:1263 → 1402

M_domain; M domain of GW182

pfam16608
Location:1446 → 1636

TNRC6-PABC_bdg; TNRC6-PABC binding domain

cd12713
Location:1632 → 1719

RRM_TNRC6C; RNA recognition motif (RRM) found in vertebrate trinucleotide repeat-containing gene 6C protein (TNRC6C)

NF033849
Location:482 → 666

ser_rich_anae_1; serine-rich protein
XM_006533110.5 → XP_006533173.2 trinucleotide repeat-containing gene 6C protein isoform X4

UniProtKB/TrEMBL

B7ZC94

Conserved Domains (5) summary

cd12713
Location:1701 → 1783

RRM_TNRC6C; RNA recognition motif in vertebrate trinucleotide repeat-containing gene 6C protein (TNRC6C)

cd14283
Location:1182 → 1219

UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins

pfam10427
Location:1070 → 1185

Ago_hook; Argonaute hook

pfam12938
Location:1263 → 1402

M_domain; M domain of GW182

pfam16608
Location:1446 → 1700

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_036156615.1 → XP_036012508.1 trinucleotide repeat-containing gene 6C protein isoform X6

UniProtKB/TrEMBL

B7ZC94

Conserved Domains (6) summary

cd14283
Location:1182 → 1219

UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins

pfam10427
Location:1070 → 1185

Ago_hook; Argonaute hook

pfam12938
Location:1261 → 1452

M_domain; M domain of GW182

pfam16608
Location:1496 → 1686

TNRC6-PABC_bdg; TNRC6-PABC binding domain

cd12713
Location:1682 → 1769

RRM_TNRC6C; RNA recognition motif (RRM) found in vertebrate trinucleotide repeat-containing gene 6C protein (TNRC6C)

NF033849
Location:482 → 666

ser_rich_anae_1; serine-rich protein
XM_030245906.2 → XP_030101766.1 trinucleotide repeat-containing gene 6C protein isoform X8

UniProtKB/Swiss-Prot

Q3UHC0, Q3UZ61, Q80TB6, Q8BXF9

UniProtKB/TrEMBL

B7ZC94

Related

ENSMUSP00000115221.2, ENSMUST00000138299.2

Conserved Domains (5) summary

cd12713
Location:1513 → 1595

RRM_TNRC6C; RNA recognition motif in vertebrate trinucleotide repeat-containing gene 6C protein (TNRC6C)

cd14283
Location:936 → 973

UBA_TNR6C; UBA domain found in trinucleotide repeat-containing gene 6C protein (TNRC6C) and similar proteins

pfam10427
Location:824 → 939

Ago_hook; Argonaute hook

pfam12938
Location:1024 → 1214

M_domain; M domain of GW182

pfam16608
Location:1258 → 1512

TNRC6-PABC_bdg; TNRC6-PABC binding domain