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    Nxnl1 nucleoredoxin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 234404, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nxnl1provided by MGI
    Official Full Name
    nucleoredoxin-like 1provided by MGI
    Primary source
    MGI:MGI:1924446
    See related
    Ensembl:ENSMUSG00000034829 AllianceGenome:MGI:1924446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RdCVF; Txnl6; A930031O08Rik
    Summary
    Involved in photoreceptor cell maintenance. Located in mitochondrion. Is expressed in several structures, including cerebellum external granule cell layer; neural retina; and olfactory epithelium. Orthologous to human NXNL1 (nucleoredoxin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in adrenal adult (RPKM 2.3), thymus adult (RPKM 1.1) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Nxnl1 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72013211..72019291, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71560555..71566649, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6652 Neighboring gene multivesicular body subunit 12A Neighboring gene transmembrane protein 221 Neighboring gene STARR-positive B cell enhancer ABC_E6653 Neighboring gene STARR-positive B cell enhancer ABC_E10508 Neighboring gene solute carrier family 27 (fatty acid transporter), member 1 Neighboring gene 6-phosphogluconolactonase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General protein information

    Preferred Names
    nucleoredoxin-like protein 1
    Names
    rod-derived cone viability factor
    thioredoxin-like 6
    thioredoxin-like protein 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145598.3NP_663573.1  nucleoredoxin-like protein 1

      See identical proteins and their annotated locations for NP_663573.1

      Status: VALIDATED

      Source sequence(s)
      AC162033
      Consensus CDS
      CCDS40385.1
      UniProtKB/Swiss-Prot
      Q8VC33, Q91W38
      Related
      ENSMUSP00000127094.2, ENSMUST00000163659.3
      Conserved Domains (1) summary
      cd03008
      Location:8153
      TryX_like_RdCVF; Tryparedoxin (TryX)-like family, Rod-derived cone viability factor (RdCVF) subfamily; RdCVF is a thioredoxin (TRX)-like protein specifically expressed in photoreceptors. RdCVF was isolated and identified as a factor that supports cone survival in retinal ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      72013211..72019291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)