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    Art5 ADP-ribosyltransferase 5 [ Mus musculus (house mouse) ]

    Gene ID: 11875, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Art5provided by MGI
    Official Full Name
    ADP-ribosyltransferase 5provided by MGI
    Primary source
    MGI:MGI:107948
    See related
    Ensembl:ENSMUSG00000070424 AllianceGenome:MGI:107948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARTC5; Yac-2
    Summary
    Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Predicted to be located in extracellular region and membrane. Is expressed in several structures, including heart; limb; male reproductive system; nose; and skeletal musculature. Orthologous to human ART5 (ADP-ribosyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 21.8), heart adult (RPKM 3.7) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Art5 in Genome Data Viewer
    Location:
    7 E2; 7 54.71 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101746086..101752052, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102096879..102100291, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interleukin 18 binding protein Neighboring gene ring finger protein 121 Neighboring gene STARR-seq mESC enhancer starr_19703 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 10 Neighboring gene STARR-seq mESC enhancer starr_19704 Neighboring gene nucleoporin 98 Neighboring gene STARR-seq mESC enhancer starr_19705 Neighboring gene post-GPI attachment to proteins 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase. Okazaki IJ, et al. J Biol Chem, 1996 Sep 6. PMID 8703012
    2. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. Glowacki G, et al. Protein Sci, 2002 Jul. PMID 12070318, Free PMC Article
    3. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. Glowacki G, et al. Gene, 2001 Sep 19. PMID 11587854
    4. Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Naillat F, et al. Biochim Biophys Acta Mol Basis Dis, 2024 Jun. PMID 38653356
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC151200, MGC151226

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ecto-ADP-ribosyltransferase 5
    Names
    ADP-ribosyltransferase C2 and C3 toxin-like 5
    NAD(P)(+)--arginine ADP-ribosyltransferase 5
    mono(ADP-ribosyl)transferase 5
    NP_001278283.1
    NP_001398914.1
    NP_001398915.1
    NP_001398916.1
    NP_001398917.1
    NP_001398918.1
    NP_001398919.1
    NP_001398920.1
    NP_001398921.1
    NP_031517.2
    XP_006507325.1
    XP_006507326.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291354.2 → NP_001278283.1  ecto-ADP-ribosyltransferase 5 isoform a precursor

      See identical proteins and their annotated locations for NP_001278283.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).
      Source sequence(s)
      AC132297
      Consensus CDS
      CCDS21525.1
      UniProtKB/Swiss-Prot
      E9QM95, P70352, Q91VF7, Q91X06, Q91X07, Q921A5
      UniProtKB/TrEMBL
      Q14AG6
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 255
      ART; NAD:arginine ADP-ribosyltransferase

    2. NM_001411985.1 → NP_001398914.1  ecto-ADP-ribosyltransferase 5 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC132297
      UniProtKB/Swiss-Prot
      E9QM95, P70352, Q91VF7, Q91X06, Q91X07, Q921A5
      UniProtKB/TrEMBL
      Q14AG6
      Related
      ENSMUSP00000091678.3, ENSMUST00000094128.9

    3. NM_001411986.1 → NP_001398915.1  ecto-ADP-ribosyltransferase 5 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC132297
      UniProtKB/TrEMBL
      Q14AG6

    4. NM_001411987.1 → NP_001398916.1  ecto-ADP-ribosyltransferase 5 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC132297
      UniProtKB/TrEMBL
      Q14AG6

    5. NM_001411988.1 → NP_001398917.1  ecto-ADP-ribosyltransferase 5 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC132297
      Related
      ENSMUSP00000102547.2, ENSMUST00000106934.2

    6. NM_001411989.1 → NP_001398918.1  ecto-ADP-ribosyltransferase 5 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC132297

    7. NM_001411990.1 → NP_001398919.1  ecto-ADP-ribosyltransferase 5 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC132297

    8. NM_001411991.1 → NP_001398920.1  ecto-ADP-ribosyltransferase 5 isoform e precursor

      Status: VALIDATED

      Source sequence(s)
      AC132297
      UniProtKB/TrEMBL
      B7ZMV7
      Related
      ENSMUSP00000102548.2, ENSMUST00000106935.8

    9. NM_001411992.1 → NP_001398921.1  ecto-ADP-ribosyltransferase 5 isoform e precursor

      Status: VALIDATED

      Source sequence(s)
      AC132297
      UniProtKB/TrEMBL
      B7ZMV7

    10. NM_007491.3 → NP_031517.2  ecto-ADP-ribosyltransferase 5 isoform a precursor

      See identical proteins and their annotated locations for NP_031517.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 4 all encode the same isoform (a).
      Source sequence(s)
      AC132297
      Consensus CDS
      CCDS21525.1
      UniProtKB/Swiss-Prot
      E9QM95, P70352, Q91VF7, Q91X06, Q91X07, Q921A5
      UniProtKB/TrEMBL
      Q14AG6
      Related
      ENSMUSP00000102550.2, ENSMUST00000106937.8
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 255
      ART; NAD:arginine ADP-ribosyltransferase

    RNA

    1. NR_111935.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon and lacks an alternate internal segment compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC132297

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101746086..101752052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507263.5 → XP_006507326.1  ecto-ADP-ribosyltransferase 5 isoform X6

      See identical proteins and their annotated locations for XP_006507326.1

      UniProtKB/Swiss-Prot
      P70352
      Conserved Domains (1) summary
      cl00173
      Location:29 → 119
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    2. XM_006507262.4 → XP_006507325.1  ecto-ADP-ribosyltransferase 5 isoform X5

      Conserved Domains (1) summary
      cl00173
      Location:29 → 160
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70352.3 GenPept UniProtKB/Swiss-Prot:P70352

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