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    Gramd2b GRAM domain containing 2B [ Mus musculus (house mouse) ]

    Gene ID: 107022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gramd2bprovided by MGI
    Official Full Name
    GRAM domain containing 2Bprovided by MGI
    Primary source
    MGI:MGI:1914815
    See related
    Ensembl:ENSMUSG00000001700 AllianceGenome:MGI:1914815
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gramd3; NS3TP2; 9030613F08Rik; 9130427A09Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be active in cytoplasmic microtubule. Orthologous to human GRAMD2B (GRAM domain containing 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E18 (RPKM 10.1), large intestine adult (RPKM 8.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gramd2b in Genome Data Viewer
    Location:
    18 D3; 18 30.43 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (56533412..56636864)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (56387485..56503792)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene crumbs homolog 1 pseudogene Neighboring gene RIKEN cDNA 4930511P09 gene Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11659 Neighboring gene STARR-positive B cell enhancer ABC_E8927 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:56615334-56615595 Neighboring gene STARR-seq mESC enhancer starr_44663 Neighboring gene glutamate-ammonia ligase (glutamine synthetase) pseudogene Neighboring gene aldehyde dehydrogenase family 7, member A1 Neighboring gene microRNA 1258

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    2. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    GRAM domain-containing protein 2B
    Names
    GRAM domain containing 3
    GRAM domain-containing protein 3
    HCV NS3-transactivated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360917.1 → NP_001347846.1  GRAM domain-containing protein 2B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC120797, AC162035
      Consensus CDS
      CCDS89243.1
      UniProtKB/Swiss-Prot
      E9Q8C6, Q6PEM6
      Related
      ENSMUSP00000157609.2, ENSMUST00000237422.2
      Conserved Domains (1) summary
      cd13220
      Location:135 → 227
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    2. NM_026240.2 → NP_080516.2  GRAM domain-containing protein 2B isoform 2

      See identical proteins and their annotated locations for NP_080516.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK164050, BE198493, BY112662
      Consensus CDS
      CCDS50290.1
      UniProtKB/TrEMBL
      Q9D2W5, Q9D318
      Related
      ENSMUSP00000068453.6, ENSMUST00000070166.6
      Conserved Domains (1) summary
      cd13220
      Location:122 → 214
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      56533412..56636864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PEM6.2 GenPept UniProtKB/Swiss-Prot:Q6PEM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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