U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dlx1 distal-less homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 13390, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dlx1provided by MGI
    Official Full Name
    distal-less homeobox 1provided by MGI
    Primary source
    MGI:MGI:94901
    See related
    Ensembl:ENSMUSG00000041911 AllianceGenome:MGI:94901
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dlx; DII B; Dlx-1
    Summary
    The protein encoded by this gene is a homeobox-containing transcription factor involved in development. The encoded protein plays a role in craniofacial patterning, as well as in bone, placenta, and sensory organ formation. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in whole brain E14.5 (RPKM 29.9), frontal lobe adult (RPKM 28.2) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dlx1 in Genome Data Viewer
    Location:
    2 C2; 2 42.61 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (71358457..71364325)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (71528113..71533981)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene histone aminotransferase 1 Neighboring gene VISTA enhancer mm55 Neighboring gene nuclear protein-NHP2-like protein pseudogene Neighboring gene methionyl aminopeptidase type 1D (mitochondrial) Neighboring gene STARR-seq mESC enhancer starr_04791 Neighboring gene STARR-seq mESC enhancer starr_04792 Neighboring gene distal-less homeobox 1, antisense Neighboring gene STARR-seq mESC enhancer starr_04793 Neighboring gene distal-less homeobox 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:71436893-71437193 Neighboring gene predicted gene, 36857

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within GABAergic neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to BMP stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to BMP stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cerebral cortex GABAergic interneuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex GABAergic interneuron fate commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within embryonic skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within forebrain neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within hippocampus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cellular response to transforming growth factor beta stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within neuroblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of oligodendrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of amacrine cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within proximal/distal pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within subpallium development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416985.1NP_001403914.1  homeobox protein DLX-1

      Status: REVIEWED

      Source sequence(s)
      AL928931
      UniProtKB/Swiss-Prot
      Q64317
    2. NM_001416986.1NP_001403915.1  homeobox protein DLX-1

      Status: REVIEWED

      Source sequence(s)
      AL928931
      UniProtKB/Swiss-Prot
      Q64317
    3. NM_001416987.1NP_001403916.1  homeobox protein DLX-1

      Status: REVIEWED

      Source sequence(s)
      AL928931
      UniProtKB/Swiss-Prot
      Q64317
    4. NM_010053.3NP_034183.1  homeobox protein DLX-1

      See identical proteins and their annotated locations for NP_034183.1

      Status: REVIEWED

      Source sequence(s)
      AL928931
      Consensus CDS
      CCDS16116.1
      UniProtKB/Swiss-Prot
      Q64317
      Related
      ENSMUSP00000042413.4, ENSMUST00000037119.4
      Conserved Domains (1) summary
      pfam00046
      Location:131185
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      71358457..71364325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498672.3XP_006498735.1  homeobox protein DLX-1 isoform X1

      See identical proteins and their annotated locations for XP_006498735.1

      UniProtKB/Swiss-Prot
      Q64317
      Conserved Domains (1) summary
      pfam00046
      Location:131185
      Homeobox; Homeobox domain