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    B4galt6 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 [ Mus musculus (house mouse) ]

    Gene ID: 56386, updated on 9-Dec-2024

    Summary

    Official Symbol
    B4galt6provided by MGI
    Official Full Name
    UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6provided by MGI
    Primary source
    MGI:MGI:1928380
    See related
    Ensembl:ENSMUSG00000056124 AllianceGenome:MGI:1928380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Involved in ganglioside biosynthetic process via lactosylceramide and neurogenesis. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and urinary system. Orthologous to human B4GALT6 (beta-1,4-galactosyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in small intestine adult (RPKM 16.5), duodenum adult (RPKM 16.3) and 23 other tissues See more
    Orthologs
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    Genomic context

    See B4galt6 in Genome Data Viewer
    Location:
    18 A2; 18 11.48 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (20817656..20879461, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (20684599..20746404, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16090 Neighboring gene ribosomal protein L35 pseudogene Neighboring gene transthyretin Neighboring gene STARR-seq mESC enhancer starr_43979 Neighboring gene predicted gene, 31437 Neighboring gene STARR-seq mESC enhancer starr_43980 Neighboring gene STARR-seq mESC enhancer starr_43983 Neighboring gene STARR-seq mESC enhancer starr_43987 Neighboring gene STARR-seq mESC enhancer starr_43988 Neighboring gene trafficking protein particle complex 8 Neighboring gene STARR-positive B cell enhancer ABC_E11655 Neighboring gene STARR-seq mESC enhancer starr_43995 Neighboring gene STARR-seq mESC enhancer starr_43996 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:21115655-21115838 Neighboring gene ring finger protein 125 Neighboring gene STARR-seq mESC enhancer starr_43997

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    beta-1,4-galactosyltransferase 6
    Names
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6
    UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6
    b4Gal-T6
    beta-1, 4-galactosyltransferase VI
    beta-1,4-GalTase 6
    beta4Gal-T6
    glucosylceramide beta-1,4-galactosyltransferase
    lacCer synthase
    lactosylceramide synthase
    NP_062711.1
    XP_030106406.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019737.2NP_062711.1  beta-1,4-galactosyltransferase 6

      See identical proteins and their annotated locations for NP_062711.1

      Status: VALIDATED

      Source sequence(s)
      AC129078, AF097158
      Consensus CDS
      CCDS29086.1
      UniProtKB/Swiss-Prot
      Q9WVK5
      UniProtKB/TrEMBL
      Q3UUA9, Q3UUN1
      Related
      ENSMUSP00000066515.6, ENSMUST00000070080.6
      Conserved Domains (1) summary
      cd00899
      Location:155371
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      20817656..20879461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250546.2XP_030106406.1  beta-1,4-galactosyltransferase 6 isoform X1

      UniProtKB/TrEMBL
      Q3TPM8, Q3UUN1
      Conserved Domains (1) summary
      cd00899
      Location:111327
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids