Rps5 ribosomal protein S5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps5provided by MGI
Official Full Name: ribosomal protein S5provided by MGI
Primary source: MGI:MGI:1097682
See related: Ensembl:ENSMUSG00000012848 AllianceGenome:MGI:1097682
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: A structural constituent of ribosome. Predicted to be involved in regulation of translational fidelity; ribosomal small subunit assembly; and translation. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in several structures, including brain; embryo ectoderm; genitourinary system; gut; and sensory organ. Orthologous to human RPS5 (ribosomal protein S5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 1722.8), large intestine adult (RPKM 951.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 7.69 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (12656223..12660613)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (12922311..12926686)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosomes from adipose-derived stem cells regulate macrophage polarization and accelerate diabetic wound healing via the circ-Rps5/miR-124-3p axis.
Title: Exosomes from adipose-derived stem cells regulate macrophage polarization and accelerate diabetic wound healing via the circ-Rps5/miR-124-3p axis.
Findings support the concept that genetic manipulation of RPS5 gene expression level (up- and/or downregulation) critically affects the potential of murine erythroleukemia cells to fully complete their erythroid maturation program in vitro.
Title: Genetic manipulation of RPS5 gene expression modulates the initiation of commitment of MEL cells to erythroid maturation: Implications in understanding ribosomopathies.
The results indicate that rpS5 protein enters the nucleus via the region 38-50 aa that forms a random coil as revealed by molecular dynamic simulation.
Title: On the intracellular trafficking of mouse S5 ribosomal protein from cytoplasm to nucleoli.
deregulation of RPS5 gene expression (constitutive expression) affects RPS5 protein level and delays both the onset of initiation of erythroid maturation and entrance in cell cycle arrest in inducer-treated MEL cells.
Title: The potential role of ribosomal protein S5 on cell cycle arrest and initiation of murine erythroleukemia cell differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124264 (e-PCR)
- UniSTS:161086

Rps5 (e-PCR), detects polymorphism
- UniSTS:259136

RH138527 (e-PCR)
- UniSTS:220614

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables rRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of translational fidelity	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational fidelity	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	ISO Inferred from Sequence Orthology more info
involved_in translation at postsynapse	NAS Non-traceable Author Statement more info	PubMed
involved_in translation at presynapse	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info
part_of cytosolic small ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in presynapse	NAS Non-traceable Author Statement more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in ribosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in ribosome	NAS Non-traceable Author Statement more info	PubMed
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small ribosomal subunit protein uS7

Names: 40S ribosomal protein S5; S5 ribosomal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417226.1 → NP_001404155.1 small ribosomal subunit protein uS7

Status: VALIDATED

Source sequence(s)

AC107704

UniProtKB/Swiss-Prot

O08607, P97461, Q91V55

UniProtKB/TrEMBL

D3Z1S8

Related

ENSMUSP00000121961.3, ENSMUST00000137329.4
NM_009095.3 → NP_033121.2 small ribosomal subunit protein uS7

See identical proteins and their annotated locations for NP_033121.2

Status: VALIDATED

Source sequence(s)

AC107704

Consensus CDS

CCDS20817.1

UniProtKB/Swiss-Prot

O08607, P97461, Q91V55

UniProtKB/TrEMBL

D3Z1S8

Related

ENSMUSP00000004554.8, ENSMUST00000004554.14

Conserved Domains (1) summary

cd14867
Location:18 → 204

uS7_Eukaryote; Eukaryota homolog of Ribosomal Protein S7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

12656223..12660613

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152810.1 → XP_036008703.1 small ribosomal subunit protein uS7 isoform X1

UniProtKB/Swiss-Prot

O08607, P97461, Q91V55

UniProtKB/TrEMBL

D3Z1S8

Related

ENSMUSP00000104179.2, ENSMUST00000108539.8

Conserved Domains (1) summary

cd14867
Location:18 → 204

uS7_Eukaryote; Eukaryota homolog of Ribosomal Protein S7