tp63.L tumor protein p63 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: tp63.L
Official Full Name: tumor protein p63 L homeolog
Primary source: Xenbase:XB-GENE-865317
Locus tag: XELAEV_18027483mg
See related: EnsemblRapid:ENSXLAG00005015321 AllianceGenome:Xenbase:XB-GENE-865317
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ket; p63; Xp63; np63; tp63; tp73l; trp63; tp73l-A
Summary: Predicted to enable DNA-binding transcription factor activity; metal ion binding activity; and transcription cis-regulatory region binding activity. Predicted to act upstream of or within apoptotic process; protein tetramerization; and regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Is expressed in anatomical system; ectoderm; mesenchyme; and pharyngeal arch. Human ortholog(s) of this gene implicated in several diseases, including ADULT syndrome; EEC syndrome (multiple); ectodermal dysplasia (multiple); orofacial cleft 8; and split hand-foot malformation 4. Orthologous to human TP63 (tumor protein p63). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 5L

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (110818110..110861292)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (100117481..100160796)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
Title: Expression of pluripotency factors in larval epithelia of the frog Xenopus: evidence for the presence of cornea epithelial stem cells.
The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4.
Title: ΔNp63 is regulated by BMP4 signaling and is required for early epidermal development in Xenopus.
The role of p63 as a negative Wnt-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.
Title: p63 antagonizes Wnt-induced transcription.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein tetramerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor protein p63 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.