PCL8 Pcl8p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PCL8
Official Full Name: Pcl8p
Primary source: SGD:S000006140
Locus tag: YPL219W
See related: AllianceGenome:SGD:S000006140; FungiDB:YPL219W; VEuPathDB:YPL219W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in negative regulation of glycogen biosynthetic process. Predicted to be located in cytoplasm. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycogen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glycogen biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	IEA Inferred from Electronic Annotation more info
part_of cyclin-dependent protein kinase holoenzyme complex	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_015105.1

Cyclin; interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; PCL8 has a paralog, PCL10, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain