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    Tmem215 transmembrane protein 215 [ Mus musculus (house mouse) ]

    Gene ID: 320500, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem215provided by MGI
    Official Full Name
    transmembrane protein 215provided by MGI
    Primary source
    MGI:MGI:2444167
    See related
    Ensembl:ENSMUSG00000046593 AllianceGenome:MGI:2444167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930001M12Rik
    Summary
    Acts upstream of or within negative regulation of retinal cell programmed cell death and sprouting angiogenesis. Predicted to be located in membrane. Orthologous to human TMEM215 (transmembrane protein 215). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 2.1), spleen adult (RPKM 1.4) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem215 in Genome Data Viewer
    Location:
    4 A5; 4 20.28 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (40472180..40475653)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (40472180..40475653)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930509K18 gene Neighboring gene STARR-seq mESC enhancer starr_09985 Neighboring gene RIKEN cDNA 4933428C19 gene Neighboring gene predicted gene, 23338 Neighboring gene STARR-seq mESC enhancer starr_09986 Neighboring gene STARR-seq mESC enhancer starr_09987 Neighboring gene STARR-positive B cell enhancer ABC_E2688 Neighboring gene aprataxin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transmembrane protein 215 promotes angiogenesis by maintaining endothelial cell survival. Liu Y, et al. J Cell Physiol, 2019 Jun. PMID 30370660, Free PMC Article
    2. Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina. Park KU, et al. Invest Ophthalmol Vis Sci, 2017 Feb 1. PMID 28199486, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results identified TMEM215 as a novel molecule involved in angiogenesis by regulating the survival of endothelial cells.
      Title: Transmembrane protein 215 promotes angiogenesis by maintaining endothelial cell survival.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of retinal cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 215

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166009.1 → NP_001159481.1  transmembrane protein 215

      See identical proteins and their annotated locations for NP_001159481.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL844182
      Consensus CDS
      CCDS18046.1
      UniProtKB/Swiss-Prot
      A7E1Z1, Q8C8R5
      UniProtKB/TrEMBL
      B7ZN35
      Related
      ENSMUSP00000136595.2, ENSMUST00000179526.2
      Conserved Domains (1) summary
      pfam15746
      Location:1 → 235
      TMEM215; TMEM215 family

    2. NM_177175.4 → NP_796149.2  transmembrane protein 215

      See identical proteins and their annotated locations for NP_796149.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK044627, CK617308
      Consensus CDS
      CCDS18046.1
      UniProtKB/Swiss-Prot
      A7E1Z1, Q8C8R5
      UniProtKB/TrEMBL
      B7ZN35
      Related
      ENSMUSP00000052129.3, ENSMUST00000049655.3
      Conserved Domains (1) summary
      pfam15746
      Location:1 → 235
      TMEM215; TMEM215 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      40472180..40475653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7E1Z1.1 GenPept UniProtKB/Swiss-Prot:A7E1Z1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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