Ric8b RIC8 guanine nucleotide exchange factor B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ric8bprovided by MGI
Official Full Name: RIC8 guanine nucleotide exchange factor Bprovided by MGI
Primary source: MGI:MGI:2682307
See related: Ensembl:ENSMUSG00000035620 AllianceGenome:MGI:2682307
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ric-8; Ric-8b
Summary: Enables G-protein alpha-subunit binding activity; guanyl-nucleotide exchange factor activity; and protein folding chaperone. Involved in G protein-coupled receptor signaling pathway and sensory perception of smell. Is active in plasma membrane. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human RIC8B (RIC8 guanine nucleotide exchange factor B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 7.7), CNS E18 (RPKM 7.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 41.63 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (84753136..84854201)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (84917268..85018337)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart.
Title: The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart.
The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate.
Title: The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate.
A crucial role for Ric-8B in development and novel insights into the signals that regulate mTORC2.
Title: Depletion of Ric-8B leads to reduced mTORC2 activity.
Olfactory-specific Ric-8b knock-out mice of mixed sex do not express the Galphaolf protein in the olfactory epithelium. The mature olfactory sensory neuron layer is reduced and cell death increased. These mice have an impaired sense of smell. Ric-8b is essential for olfactory function, and it may also be essential for Galphaolf-dependent functions in the brain.
Title: Conditional Deletion of Ric-8b in Olfactory Sensory Neurons Leads to Olfactory Impairment.
Data show that the localization of maternally expressed RIC8 protein is highly dynamic and is dependent on the stage of folliculogenesis, oogenesis and cleavage, and imply that it may have a regulatory function in mammalian gametogenesis.
Title: Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis.
Results indicate that a functional N-terminus in C/EBPbeta-LAP* is required for interacting with SWI/SNF and for Ric-8B gene repression in osteoblasts.
Title: A functional N-terminal domain in C/EBPβ-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts.
a new role of Ric-8B in the crosstalk of two distinct G protein signaling pathways, which are possibly involved in a part of mechanisms of chronic heart failure.
Title: Increased ubiquitination and the crosstalk of G protein signaling in cardiac myocytes: involvement of Ric-8B in Gs suppression by Gq signal.
data suggest that Ric-8 proteins are molecular chaperones required for the initial association of nascent Galpha subunits with cellular membranes
Title: Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association.
Data show that the Ric-8B gene is negatively regulated during osteoblast differentiation by the transcription factor C/EBPbeta.
Title: The Ric-8B gene is highly expressed in proliferating preosteoblastic cells and downregulated during osteoblast differentiation in a SWI/SNF- and C/EBPbeta-mediated manner.
Ric-8BFL-catalyzed nucleotide exchange probably proceeds in the forward direction to produce Galpha-GTP in cells.
Title: Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein alpha-subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein folding chaperone	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of smell	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: synembryn-B

Names: resistance to inhibitors of cholinesterase 8 homolog B; resistance to inhibitors of cholinesterase 8B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013441.2 → NP_001013459.1 synembryn-B isoform 1

See identical proteins and their annotated locations for NP_001013459.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AY940667, BC040762, BY272676

Consensus CDS

CCDS24084.1

UniProtKB/Swiss-Prot

Q58L65, Q80XE1

Related

ENSMUSP00000093032.4, ENSMUST00000095385.5

Conserved Domains (1) summary

pfam10165
Location:66 → 483

Ric8; Guanine nucleotide exchange factor synembryn
NM_183172.2 → NP_898995.1 synembryn-B isoform 2

See identical proteins and their annotated locations for NP_898995.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2, which is longer than isoform 1.

Source sequence(s)

BC040762, BC051080, BY272676

Consensus CDS

CCDS24085.1

UniProtKB/Swiss-Prot

Q80XE1

Related

ENSMUSP00000046981.8, ENSMUST00000038523.15

Conserved Domains (1) summary

pfam10165
Location:66 → 537

Ric8; Guanine nucleotide exchange factor synembryn

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

84753136..84854201

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155776.1 → XP_036011669.1 synembryn-B isoform X2

Conserved Domains (1) summary

pfam10165
Location:66 → 493

Ric8; Guanine nucleotide exchange factor synembryn
XM_036155777.1 → XP_036011670.1 synembryn-B isoform X3

Conserved Domains (1) summary

pfam10165
Location:66 → 451

Ric8; Guanine nucleotide exchange factor synembryn
XM_006513625.4 → XP_006513688.1 synembryn-B isoform X1

Conserved Domains (1) summary

pfam10165
Location:66 → 524

Ric8; Guanine nucleotide exchange factor synembryn